小鼠b波突变体
Mouse b-wave mutants.
作者信息
Pardue Machelle T, Peachey Neal S
机构信息
Rehabilitation Research and Development Center of Excellence, Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA, 30033, USA.
出版信息
Doc Ophthalmol. 2014 Apr;128(2):77-89. doi: 10.1007/s10633-013-9424-8. Epub 2014 Jan 7.
Abstract
The b-wave is a major component of the electroretinogram that reflects the activity of depolarizing bipolar cells (DBCs). The b-wave is used diagnostically to identify patients with defects in DBC signaling or in transmission from photoreceptors to DBCs. In mouse models, an abnormal b-wave has been used to demonstrate a critical role of a particular protein in the release of glutamate from photoreceptor terminals, in establishing the structure of the photoreceptor-to-DBC synapse, in DBC signal transduction, and also in DBC development, survival, or metabolic support. The purpose of this review is to summarize these models and how they have advanced our understanding of outer retinal function.
摘要
b波是视网膜电图的主要成分，反映去极化双极细胞（DBCs）的活动。b波在诊断上用于识别DBC信号传导或从光感受器到DBCs的传递存在缺陷的患者。在小鼠模型中，异常的b波已被用于证明特定蛋白质在光感受器终末谷氨酸释放、建立光感受器到DBC突触的结构、DBC信号转导以及DBC发育、存活或代谢支持中的关键作用。本综述的目的是总结这些模型以及它们如何增进了我们对视网膜外层功能的理解。
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