Swanson P E, Cherwitz D L, Neumann M P, Wick M R
J Cutan Pathol. 1987 Apr;14(2):65-86. doi: 10.1111/j.1600-0560.1987.tb00477.x.
In an attempt to characterize the immunocytochemical attributes of eccrine sweat gland carcinoma, we studied 32 examples of this tumor with antibodies to epithelial membrane antigen (EMA), cytokeratin (CK), carcinoembryonic antigen, S100 protein, alpha-lactalbumin, salivary amylase, blood group isoantigens, beta-2-microglobulin, and Leu M1. All cases expressed EMA and CK, and 28 of 32 cases also displayed at least 2 of the 6 remaining antigens. No significant variations were noted in the immunophenotypes of histologic subtypes of eccrine carcinoma. These results provide an objective means of diagnostic separation between sweat gland carcinoma and other primary malignant cutaneous tumors. However, they do not appear to correlate with the degree of tumoral differentiation, and are of no assistance in the separation of benign and malignant sudoriferous neoplasms. The ability of immunocytochemical techniques to distinguish between primary malignant adnexal cutaneous tumors and metastases to the skin appears unlikely, but remains to be studied further. Also, the use of immunostaining panels is advised in the study of adnexal carcinomas, since no single determinant in isolation is specific for these neoplasms.
为了描述小汗腺癌的免疫细胞化学特征，我们用抗上皮膜抗原（EMA）、细胞角蛋白（CK）、癌胚抗原、S100蛋白、α-乳白蛋白、唾液淀粉酶、血型同种抗原、β2-微球蛋白和Leu M1的抗体研究了32例该肿瘤。所有病例均表达EMA和CK，32例中有28例还显示出其余6种抗原中的至少2种。在小汗腺癌的组织学亚型的免疫表型中未观察到显著差异。这些结果提供了一种在汗腺癌与其他原发性皮肤恶性肿瘤之间进行诊断区分的客观方法。然而，它们似乎与肿瘤分化程度无关，并且在区分良性和恶性汗腺肿瘤方面没有帮助。免疫细胞化学技术区分原发性皮肤附属器恶性肿瘤和皮肤转移瘤的能力似乎不太可能，但仍有待进一步研究。此外，在附属器癌的研究中建议使用免疫染色组合，因为单独的任何一个决定因素都不是这些肿瘤所特有的。
