Kanitakis J, Zambruno G, Viac J, Panzini H, Thivolet J
J Am Acad Dermatol. 1987 Aug;17(2 Pt 1):187-91. doi: 10.1016/s0190-9622(87)70188-1.
The expression of two immunohistochemical markers of neural tissue and of cutaneous sweat glands (S-100 protein and Leu-7 antigen) was studied in a group of cutaneous epithelial, mostly glandular, tumors. These antigens were detected only on sweat gland neoplasms showing both types (eccrine and apocrine) of differentiation. These results suggest that antibodies to S-100 protein and to Leu-7 antigen have a limited value in the distinction between eccrine and apocrine tumours, but they may serve as a useful adjunct for the confirmation of the glandular differentiation of cutaneous epithelial tumors.
在一组皮肤上皮肿瘤（主要是腺性肿瘤）中，研究了神经组织和皮肤汗腺的两种免疫组化标志物（S-100蛋白和Leu-7抗原）的表达情况。仅在显示出两种类型（外分泌型和顶浆分泌型）分化的汗腺肿瘤中检测到这些抗原。这些结果表明，抗S-100蛋白和抗Leu-7抗原的抗体在区分外分泌型和顶浆分泌型肿瘤方面价值有限，但它们可能作为一种有用的辅助手段，用于确认皮肤上皮肿瘤的腺性分化。
