Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Mov Disord. 2014 Feb;29(2):203-6. doi: 10.1002/mds.25773. Epub 2014 Jan 2.
Deep brain stimulation (DBS) in Parkinson's disease (PD) is frequency-dependent. Past studies of the effect of DBS frequency, however, involved scrutiny of too few frequencies to eliminate risk of undersampling. Also, these studies presented averaged measures across subjects; high intersubject variability makes these measures problematic. In this study, 6 subjects with PD were tested in a drug-minimal state. Following 10 minutes of stimulation at the new frequency, all available frequencies were tested. Hand-opening and hand-closing amplitude and frequency were measured in 3 epochs of 15 seconds each. Multiple frequencies (low and high) resulted in peaks of increased movement amplitudes. Peaks were specific and varied among individuals. No clear relationship between stimulation frequency and movement frequency was discovered. In light of the findings, a wider range of stimulation frequencies should be examined, particularly lower frequencies. Most current theories of PD pathophysiology and DBS mechanisms of action fail to explain results of the kind demonstrated herein.
脑深部电刺激（DBS）在帕金森病（PD）中是频率依赖性的。然而，过去关于 DBS 频率影响的研究只涉及到少数几个频率，以消除抽样不足的风险。此外，这些研究在对受试者进行了平均测量；高的受试者间变异性使得这些测量结果存在问题。在这项研究中，6 名患有 PD 的患者在药物最小状态下进行了测试。在新频率刺激 10 分钟后，测试了所有可用的频率。在每个 15 秒的 3 个时段中测量手张开和手闭合的幅度和频率。多个频率（低和高）导致运动幅度增加的峰值。这些峰值是特定的，并且在个体之间有所不同。没有发现刺激频率与运动频率之间的明确关系。鉴于这些发现，应该检查更广泛的刺激频率，特别是较低的频率。目前大多数 PD 病理生理学和 DBS 作用机制的理论都无法解释本文所展示的结果。
