Canepa P, Orsi A, Martini M, Icardi G
Department of Health Sciences, University of Genoa, Italy.
J Prev Med Hyg. 2013 Jun;54(2):61-70.
Human Papillomavirus (HPV) has a significant impact in male's health, as cause of clinical manifestations ranging from genital warts to several cancers of the anogenital and aero-digestive tract. HPV types which most frequently affect men are 6, 11, 16 and 18, included in the HPV quadrivalent vaccine, recently approved for use in males by Food and Drug Administration (FDA) and European Medicines Agency (EMA). Although several data about the safety and efficacy of quadrivalent vaccine are available, the implementation of proper immunization plans dedicate to male's population cannot ignore the knowledge of the characteristics of the disease in men, which in some aspects should be clarify, in particular clearance of type-specific HPV infections and transmission dynamics. Purpose of this review is to summarise the main information about the burden and the natural history of the HPV related disease in males.
人乳头瘤病毒（HPV）对男性健康有重大影响，可导致从尖锐湿疣到多种肛门生殖器和上呼吸道消化道癌症等一系列临床表现。最常感染男性的HPV类型为6型、11型、16型和18型，这些都包含在HPV四价疫苗中，该疫苗最近已获美国食品药品监督管理局（FDA）和欧洲药品管理局（EMA）批准用于男性。尽管已有若干关于四价疫苗安全性和有效性的数据，但制定针对男性人群的适当免疫计划不能忽视对男性疾病特征的了解，其中某些方面仍需阐明，特别是特定类型HPV感染的清除情况和传播动态。本综述的目的是总结有关男性HPV相关疾病负担和自然史的主要信息。
