Kurokawa Toshio, Park Masami, Ueda Naoko
Department of Ophthalmology, Kyoto Hakuaikai Hospital.
Nippon Ganka Gakkai Zasshi. 2013 Nov;117(11):918-24.
Aquired transsynaptic retrograde degeneration of the human visual system can be identified using magnetic resonance imaging (MRI) and optical coherence tomography (OCT), which can reveal optic tract atrophy, retinal nerve fiber layer loss, and ganglion cell complex (GCC) thinning. We investigated GCC changes in the first 4 years following post-geniculate lesions.
Nine patients with congruous homonymous hemianopia were scanned with OCT. A 6-mm circle centered on the macula was divided vertically into hemianopia (H) and unaffected (U) sides. GCC and retinal thicknesses were calculated using an average for both eyes and compared with the hemianopia/unaffected side (H/U) ratio. The relationship between the H/U ratio of GCC and time elapsed since occipital damage was evaluated.
The average GCC thicknesses was 89.1 and 96.6 microm, and of the retina 295.7 microm and 292.7 microm in the H and U sides, respectively. The H/U ratio of GCC at 0.92 was significantly lower than of the retina at 0.99 (p=0.042). Regression analysis revealed a negative linear relationship (linear regression r= -0.868, p= 0.012) described by the equation: H/U ratio of GCC = 0.99 - 0.004 x elapsed time (months).
For 4 years following post-geniculate damage, GCC on the hemianopia side decreased approximately 5% per year while the retinal thickness was almost unchanged.
利用磁共振成像（MRI）和光学相干断层扫描（OCT）可识别获得性人类视觉系统跨突触逆行性变性，其可揭示视束萎缩、视网膜神经纤维层缺失和神经节细胞复合体（GCC）变薄。我们研究了膝状体后病变后最初4年内GCC的变化。
对9例一致性同侧偏盲患者进行OCT扫描。以黄斑为中心的6毫米圆圈垂直分为偏盲（H）侧和未受影响（U）侧。使用双眼平均值计算GCC和视网膜厚度，并与偏盲/未受影响侧（H/U）比值进行比较。评估GCC的H/U比值与枕叶损伤后经过时间之间的关系。
H侧和U侧GCC的平均厚度分别为89.1微米和96.6微米，视网膜的平均厚度分别为295.7微米和292.7微米。GCC的H/U比值为0.92，显著低于视网膜的H/U比值0.99（p = 0.042）。回归分析显示出负线性关系（线性回归r = -0.868，p = 0.012），由以下方程描述：GCC的H/U比值 = 0.99 - 0.004×经过时间（月）。
在膝状体后损伤后的4年里，偏盲侧的GCC每年大约减少5%，而视网膜厚度几乎没有变化。
