Eliseeva N M, Serova N K, Erichev V P, Panyushkina L A
Burdenko Scientific Research Neurosurgery Institute, 16 4-ya Tverskaya-Yamskaya St., Moscow, Russian Federation, 125047.
Research Institute of Eye Diseases, 11 A,B, Rossolimo St., Moscow, Russian Federation, 119021.
Vestn Oftalmol. 2017;133(4):25-30. doi: 10.17116/oftalma2017133425-30.
To establish the possibility of retrograde trans-synaptic neural degeneration following acquired post-geniculate visual pathway damage.
Twenty-two patients with homonymous hemianopia caused by acquired post-geniculate visual pathway damage were examined. Peripapillary retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) measurements were assessed with RTVue-100 Fourier-domain optical coherence tomography (OCT).
In 12 out of 22 patients we detected binocular GCC thinning that was ipsilateral to post-geniculate involvement. Nine patients showed a decrease in the RNFL thickness. However, topographic correspondence between the post-geniculate lesion and RNFL thickness was established for 2 of them only. GCC thinning was more common in patients with hemianopsia acquired more than 6 months ago (p<0.0009).
Having assessed the ganglion cell complex and retinal nerve fiber layer with OCT, we have proved possible that trans-synaptic retrograde degeneration develops in patients with post-geniculate visual pathway damage.
探讨膝状体后视觉通路损伤后发生逆行性跨突触神经变性的可能性。
对22例因膝状体后视觉通路损伤导致同向性偏盲的患者进行检查。使用RTVue - 100傅里叶域光学相干断层扫描（OCT）评估视乳头周围视网膜神经纤维层（RNFL）厚度和神经节细胞复合体（GCC）。
22例患者中有12例检测到与膝状体后受累同侧的双眼GCC变薄。9例患者RNFL厚度降低。然而，仅其中2例患者的膝状体后病变与RNFL厚度之间建立了地形对应关系。GCC变薄在6个月前以上发生偏盲的患者中更为常见（p<0.0009）。
通过OCT评估神经节细胞复合体和视网膜神经纤维层，我们证明了膝状体后视觉通路损伤患者可能发生跨突触逆行变性。
