Yahata H, Fukuda Y, Asahara T, Ono E, Dohi K
Jpn J Exp Med. 1986 Dec;56(6):257-64.
The induction kinetics of human suppressor cells in unidirectional mixed lymphocyte culture (MLC) and the E-receptor of the suppressor cells were studied. Suppressor cell function was measured by the degree of suppression of mixed lymphocyte reaction (MLR). MLR suppressor cells appeared 3 days after priming MLC was started, and maintained the same suppressive effect until the 11th day. These suppressor cells were allo-antigen specific and resistant to x-irradiation up to 1000 rad, but susceptible to 1500 rad or to mitomycin C treatment. MLR suppressor cells which were obtained from priming MLC after 3 to 8 days formed rosettes with sheep erythrocytes at 37 degrees C.
研究了单向混合淋巴细胞培养（MLC）中人类抑制细胞的诱导动力学以及抑制细胞的E受体。通过混合淋巴细胞反应（MLR）的抑制程度来测定抑制细胞功能。MLR抑制细胞在启动MLC开始后3天出现，并维持相同的抑制效果直至第11天。这些抑制细胞具有同种异体抗原特异性，对高达1000拉德的X射线照射有抗性，但对1500拉德或丝裂霉素C处理敏感。在3至8天后从启动的MLC中获得的MLR抑制细胞在37℃下与绵羊红细胞形成花环。
