Schnellbacher K, Marsovszky E, Roskamm H
J Cardiovasc Pharmacol. 1986;8 Suppl 11:S143-7. doi: 10.1097/00005344-198511001-00026.
Twelve patients with stable angina pectoris due to coronary heart disease received single oral doses of 5, 10, and 20 mg bisoprolol in a placebo-controlled double-blind crossover study. A significant, dose-related increase in exercise tolerance in symptom-limited bicycle exercise tests performed 2.5 h after administration (p less than 0.05) was demonstrated. The dose-effect relationship was especially marked in reduction of heart rate, rate-pressure product, and ischemic ST-segment depression at the highest comparable workload (p less than 0.01). Compared with placebo, mean improvements in work performance (determined by the maximal workload attained, i.e., W X minutes) increased to 105% with 5 mg, to 122% with 10 mg, and to 131% with 20 mg bisoprolol. The lower incidence rate of exercise-induced symptoms of angina pectoris at an identical workload was marked at the 10- and 20-mg dose.
在一项安慰剂对照的双盲交叉研究中，12例因冠心病导致稳定型心绞痛的患者接受了单次口服5毫克、10毫克和20毫克比索洛尔治疗。结果显示，给药后2.5小时进行的症状限制性自行车运动试验中，运动耐量有显著的剂量相关增加（p<0.05）。在最高可比工作量下，心率、心率-血压乘积和缺血性ST段压低的降低方面，剂量效应关系尤为明显（p<0.01）。与安慰剂相比，工作表现的平均改善（由达到的最大工作量确定，即W×分钟）在服用5毫克比索洛尔时增至105%，10毫克时增至122%，20毫克时增至131%。在相同工作量下，10毫克和20毫克剂量时运动诱发的心绞痛症状发生率较低。
