Zhang Pingjing, Chen Jianxin, Li Tiejun, Zhu York Yuanyuan
Biomics Biotechnologies Co. Ltd, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016, and Small RNA Technology and Application Institute, Nantong University, Economic & Technology Development Area, Jiangsu, The People's Republic of China 226016.
J Cosmet Sci. 2013 Nov-Dec;64(6):455-68.
Over the past two decades, RNA interference (RNAi) has achieved great improvements in medicine, which has benefited the development of innovative cosmeceutical products, particular, to antiaging cosmeceuticals. A variety of ongoing research has tried to employ small RNAs-small interference RNA and microRNA as new cosmeceutical ingredients. Furthermore, several skin care companies have released new small RNA products in cosmetic market. In this review, we will describe the latest and most advanced approaches and strategies of using small RNA as antiaging cosmetics, including investigations on aging-related genes that small RNA target, method of delivering them, and challenges in the development of RNAi-based therapeutics for skin care cosmeceuticals. It is certain that advancement in this direction will evolve a new landscape for innovative antiaging cosmeceuticals.
在过去二十年中，RNA干扰（RNAi）在医学领域取得了巨大进展，这有利于创新药妆产品的开发，尤其是抗衰老药妆产品。各种正在进行的研究试图将小RNA——小干扰RNA和微小RNA用作新的药妆成分。此外，几家护肤品公司已在化妆品市场推出了新的小RNA产品。在本综述中，我们将描述使用小RNA作为抗衰老化妆品的最新和最先进的方法与策略，包括对小RNA靶向的衰老相关基因的研究、递送它们的方法以及用于护肤药妆品的基于RNA干扰的疗法开发中的挑战。可以肯定的是，这一方向的进展将为创新抗衰老药妆品带来新的局面。
