Trăistaru Rodica, Enăchescu Viorela, Kamal Diana, Foarfă Camelia, Rogoveanu Otilia
Department of Physical Medicine and Rehabilitation, University of Medicine and Pharmacy of Craiova, Romania;
Rom J Morphol Embryol. 2013;54(4):1125-34.
Gout is a type of inflammatory arthropathy that affects the peripheral joints and results from the accumulation of monosodium urate (MSU) crystals in the synovial fluid and other tissues. This disease is the most common form of inflammatory arthritis in men over 40 years of age. The fundamental biochemical abnormality in gout is an increase in serum urate (SU) concentration. These needle-like crystals induce not only acute episodes of inflammatory process into the surrounding area, but also, in the long-term history of the disease, chronic inflammation that is associated with changes in articular and periarticular structures. The next step caused by deposited MSU crystals is represented by the tophus formation and chronic gouty synovitis. The presence of tophi has been associated with greater physical functional disability in gout patients. We presented a case of severe chronic tophaceous gout in a 48-year-old man with chronic hand arthritis and urolithiasis, to point the significance of complex assessment (clinical, functional, imagistic and histological exams) in the diagnosis of a soft tissue lesion, especially in hands.
痛风是一种炎症性关节病，影响外周关节，由滑膜液和其他组织中尿酸钠（MSU）晶体的积聚引起。这种疾病是40岁以上男性中最常见的炎症性关节炎形式。痛风的基本生化异常是血清尿酸（SU）浓度升高。这些针状晶体会引发炎症过程的急性发作，不仅会扩散到周围区域，而且在疾病的长期发展过程中，还会引发与关节和关节周围结构变化相关的慢性炎症。沉积的MSU晶体引发的下一步变化表现为痛风石形成和慢性痛风性滑膜炎。痛风石的存在与痛风患者更大的身体功能残疾有关。我们报告了一例48岁男性严重慢性痛风石性痛风病例，该患者患有慢性手部关节炎和尿路结石，以强调综合评估（临床、功能、影像学和组织学检查）在诊断软组织病变，尤其是手部病变中的重要性。
