Frumenzio Emanuela, Maglia Daniele, Salvini Eleonora, Giovannozzi Silvia, Di Biase Manuel, Bini Vittorio, Costantini Elisabetta
Clinica Urologica e Andrologica di Perugia, Università degli Studi di Perugia.
Arch Ital Urol Androl. 2013 Dec 31;85(4):197-9. doi: 10.4081/aiua.2013.4.197.
Aim of this study is to evaluate the efficacy of a phytotherapic which includes Solidago, Orthosiphon and Birch extract (Cistimev®) in association with antibiotic prophylaxis in female patients affected by recurrent urinary tract infections (UTIr).
Patients affected by UTIr older than 18 years started a 3-months antibiotic prophylaxis (Prulifloxacin 600 mg, 1 cps/week or Phosphomicyn 1 cachet/week) according to antibiogram after urine culture. The patients were divided in 2 groups: Group A: antibiotic prophylaxis plus phytotherapy (1 cps/die for 3 months) and Group B: antibiotic prophylaxis alone.
164 consecutive patients were studied: 107 were included in group A (mean age 59 ± 17.3 years) and 57 (mean age 61 ± 15.7) in group B. During the treatment period the relapse frequencies between the two groups were not significantly different (p = 0.854): 12/107 (11.21%) patients interrupted the treatment for UTIr in group A and 6/57 (10.52%) in group B. In the long term follow-up the relapse UTI risk was significant different in the two groups with a relapse risk 2.5 greater in group B than in group A (p < 0.0001).
Our study demonstrated that in female patients affected by recurrent UTI, the association between antibiotic prophylaxis and of a phytotherapic which includes Solidago, Orthosiphon and Birch extract reduced the number of UTI in the 12 months following the end of prophylaxis and obtained a longer relapsing time, greatly improving the quality of life of the patients.
本研究旨在评估一种包含一枝黄花、猫须草和桦树提取物（Cistimev®）的植物疗法与抗生素预防联合应用于复发性尿路感染（UTIr）女性患者的疗效。
年龄超过18岁的UTIr患者在尿培养后根据药敏试验开始为期3个月的抗生素预防（普卢利沙星600mg，每周1次或磷霉素，每周1片）。患者分为2组：A组：抗生素预防加植物疗法（每日1片，共3个月）；B组：仅抗生素预防。
共研究了164例连续患者：A组纳入107例（平均年龄59±17.3岁），B组纳入57例（平均年龄61±15.7岁）。在治疗期间，两组间的复发频率无显著差异（p = 0.854）：A组有12/107（11.21%）的患者因UTIr中断治疗，B组有6/57（10.52%）。在长期随访中，两组的UTI复发风险有显著差异，B组的复发风险比A组高2.5倍（p < 0.0001）。
我们的研究表明，在复发性UTI的女性患者中，抗生素预防与包含一枝黄花、猫须草和桦树提取物的植物疗法联合应用可减少预防结束后12个月内的UTI次数，并获得更长的复发时间，极大地改善了患者的生活质量。
