1Associate Editor of Science Signaling, American Association for the Advancement of Science, 1200 New York Avenue, N.W., Washington, DC 20005, USA.
Sci Signal. 2014 Jan 7;7(307):eg1. doi: 10.1126/scisignal.2005013.
The editorial staff and distinguished scientists in the field of cell signaling nominated diverse research as advances for 2013. Breakthroughs in understanding how spatial and temporal signals control cellular behavior ranged from filtering high-frequency stimuli to interpreting circadian inputs. This year's nominations also highlight the importance of understanding cell signaling in the context of physiology and disease, such as links between the nervous system and cancer. Furthermore, the application of new techniques to study cell signaling--such as optogenetics, DNA editing with CRISPR-Cas9, and sequencing untranslated regions of transcripts--continues to expand the realm and impact of signaling research.
编辑人员和细胞信号领域的杰出科学家提名了各种研究进展作为 2013 年的突破。在理解时空信号如何控制细胞行为方面的突破，从过滤高频刺激到解释昼夜节律输入。今年的提名还强调了在生理和疾病背景下理解细胞信号的重要性，例如神经系统和癌症之间的联系。此外，将新技术应用于研究细胞信号——如光遗传学、CRISPR-Cas9 介导的 DNA 编辑和转录本非翻译区的测序——继续扩大了信号研究的范围和影响。
