Sci Signal. 2010 Jan 5;3(103):eg1. doi: 10.1126/scisignal.3103eg1.
Nominations for this year's signaling breakthroughs spanned physiology, therapeutics and drug development, neuroscience, and plant signaling. Among the most exciting advances in mammalian biology were therapeutic applications of research that are overturning the conventional boundaries of signaling pathways,unexpected mechanisms to prolong life and prevent aging, new insights into schizophrenia and memory, development of a transgenic primate model, and the discovery that the cells in the lungs can "taste" noxious substances. In plant signaling,the nominations converged on the identification of the elusive receptor for the plant stress hormone abscisic acid. Finally, methodological advances were also noted with new techniques in synthetic biology enabling the precise spatiotemporal control of signaling events and increasingly facile methods for creation and analysis of proteomic data yielding tremendous increases in raw data and insights into cellular regulation.
今年的信号转导突破奖提名涵盖了生理学、治疗学和药物开发、神经科学和植物信号转导等领域。在哺乳动物生物学领域最令人兴奋的进展中，有一些研究的治疗应用正在颠覆信号通路的传统界限，揭示了延长寿命和预防衰老的意外机制，为精神分裂症和记忆提供了新的见解，开发了转基因灵长类动物模型，以及发现肺部细胞可以“品尝”到有害物质。在植物信号转导方面，提名集中在鉴定植物应激激素脱落酸的难以捉摸的受体上。最后，方法学的进展也得到了认可，合成生物学中的新技术能够精确地控制信号事件的时空，并为创建和分析蛋白质组数据提供了越来越方便的方法，从而大大增加了原始数据并深入了解细胞调控。
