Elliott P J, Iversen S D
Neuropharmacology. 1987 May;26(5):419-22. doi: 10.1016/0028-3908(87)90021-9.
The substance P (SP) antagonists (D-Pro4, D-Trp7,9, Leu11) SP(4-11), (D-Pro4, D-Trp7,9, Phe11)SP(4-11) and (D-Pro4, D-Trp7,9,10, Leu11) SP (4-11) were infused into the lateral ventricles (i.c.v.) and their effects on spontaneous and drug-induced locomotor activity were investigated. The drug DiMeC7, the stable substance P agonist, was used to stimulate locomotor activity because of its prolonged action. Only (D-Pro4, D-Trp7,9,10) SP (4-11) was found to attenuate the drug-induced increases in motor activity, indicating that it is a substance P antagonist with activity in the CNS.
将P物质（SP）拮抗剂（D-脯氨酸4、D-色氨酸7,9、亮氨酸11）SP(4 - 11)、（D-脯氨酸4、D-色氨酸7,9、苯丙氨酸11）SP(4 - 11)和（D-脯氨酸4、D-色氨酸7,9,10、亮氨酸11）SP(4 - 11)注入侧脑室（脑室内），并研究它们对自发和药物诱导的运动活动的影响。由于其作用时间延长，稳定的P物质激动剂药物DiMeC7被用于刺激运动活动。仅发现（D-脯氨酸4、D-色氨酸7,9,10）SP(4 - 11)可减弱药物诱导的运动活动增加，表明它是一种在中枢神经系统中具有活性的P物质拮抗剂。
