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卡路里成瘾的新兴神经生物学。

The emerging neurobiology of calorie addiction.

作者信息

García-Cáceres Cristina, Tschöp Matthias H

机构信息

Cristina García-Cáceres is at the Helmholtz Diabetes Center, Helmholtz Zentrum München, Munich, Germany

出版信息

Elife. 2014;3:e01928. doi: 10.7554/eLife.01928. Epub 2014 Jan 7.

DOI:10.7554/eLife.01928
PMID:24399459
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3882917/
Abstract

The response of the brain to sugar is determined by specific cell populations in the brain, including neurons that secrete melanin-concentrating hormone, and culminates in the release of dopamine.

摘要

大脑对糖的反应由大脑中的特定细胞群决定,包括分泌促黑素细胞激素的神经元,最终导致多巴胺的释放。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e79/3882917/bdf214af1217/elife01928f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e79/3882917/bdf214af1217/elife01928f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3e79/3882917/bdf214af1217/elife01928f001.jpg

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本文引用的文献

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Mol Metab. 2013 Dec 5;3(1):73-80. doi: 10.1016/j.molmet.2013.10.007. eCollection 2014 Feb.
2
Hypothalamic melanin concentrating hormone neurons communicate the nutrient value of sugar.下丘脑促黑素细胞激素神经元传递糖的营养价值。
Elife. 2013 Dec 31;2:e01462. doi: 10.7554/eLife.01462.
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Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors.人工甜味剂通过独立于甜味受体的途径刺激脂肪生成和抑制脂肪分解。
J Biol Chem. 2013 Nov 8;288(45):32475-32489. doi: 10.1074/jbc.M113.514034. Epub 2013 Sep 24.
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Gustatory stimuli representing different perceptual qualities elicit distinct patterns of neuropeptide secretion from taste buds.代表不同感觉性质的味觉刺激从味蕾中引出不同模式的神经肽分泌。
J Neurosci. 2013 Apr 24;33(17):7559-64. doi: 10.1523/JNEUROSCI.0372-13.2013.
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Adverse effects of high-intensity sweeteners on energy intake and weight control in male and obesity-prone female rats.高强度甜味剂对雄性和易肥胖雌性大鼠能量摄入及体重控制的不良影响。
Behav Neurosci. 2013 Apr;127(2):262-74. doi: 10.1037/a0031717. Epub 2013 Feb 11.
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Role of orexin/hypocretin in conditioned sucrose-seeking in rats.食欲肽/下丘脑分泌素在大鼠条件性蔗糖觅药中的作用。
Psychopharmacology (Berl). 2013 Mar;226(1):155-65. doi: 10.1007/s00213-012-2902-y. Epub 2012 Oct 25.
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Short-term consumption of sucralose, a nonnutritive sweetener, is similar to water with regard to select markers of hunger signaling and short-term glucose homeostasis in women.短期摄入三氯蔗糖(一种非营养性甜味剂)对女性的饥饿信号和短期葡萄糖稳态的选择标志物与水相似。
Nutr Res. 2011 Dec;31(12):882-8. doi: 10.1016/j.nutres.2011.10.004.
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Leptin regulates the reward value of nutrient.瘦素调节营养的奖赏价值。
Nat Neurosci. 2011 Nov 13;14(12):1562-8. doi: 10.1038/nn.2977.
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Effects of carbohydrate sugars and artificial sweeteners on appetite and the secretion of gastrointestinal satiety peptides.碳水化合物糖和人工甜味剂对食欲和胃肠道饱腹感肽分泌的影响。
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