通过差分脉冲伏安法测量地西泮和Ro 15 - 1788对麻醉和清醒自由活动大鼠纹状体细胞外抗坏血酸、3,4-二羟基苯乙酸（DOPAC）和5-羟吲哚乙酸（5-HIAA）的影响。
The effect of diazepam and Ro 15-1788 on extracellular ascorbic acid, DOPAC and 5-HIAA in the striatum of anaesthetized and conscious freely moving rats, as measured by differential pulse voltammetry.
作者信息
Crespi F, Keane P E
出版信息
Neurosci Res. 1987 Apr;4(4):323-9. doi: 10.1016/0168-0102(87)90049-6.
The effects of diazepam (10 mg/kg i.p.) and the central benzodiazepine receptor antagonist, Ro 15-1788 (30 mg/kg i.p.), on extracellular ascorbate, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindoleacetic acid (5-HIAA) were examined using differential pulse voltammetry in anaesthetized and freely moving rats. In anaesthetized animals, diazepam did not significantly alter the heights of peak 1 (ascorbate) or peak 3 (5-HIAA), but significantly reduced that of peak 2 (DOPAC). In freely moving rats, diazepam greatly reduced the heights of all 3 peaks. Ro 15-1788, injected 2 h after diazepam, reversed the effect of diazepam on peak 3, but not on peaks 1 and 2.
采用微分脉冲伏安法，在麻醉和自由活动的大鼠中研究了地西泮（腹腔注射10mg/kg）和中枢苯二氮䓬受体拮抗剂Ro 15 - 1788（腹腔注射30mg/kg）对细胞外抗坏血酸、3,4 - 二羟基苯乙酸（DOPAC）和5 - 羟吲哚乙酸（5 - HIAA）的影响。在麻醉动物中，地西泮未显著改变峰1（抗坏血酸）或峰3（5 - HIAA）的高度，但显著降低了峰2（DOPAC）的高度。在自由活动的大鼠中，地西泮大大降低了所有3个峰的高度。在注射地西泮2小时后注射Ro 15 - 1788，可逆转地西泮对峰3的作用，但对峰1和峰2无此作用。
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