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乳腺癌手术中抗生素预防的全国性实践。

National practice in antibiotic prophylaxis in breast cancer surgery.

作者信息

Eroglu Aydan, Karasoy Durdu, Kurt Halil, Baskan Semih

机构信息

Department of General Surgery and Surgical Oncology, Ankara University Medical School, Ankara, Turkey.

Department of Statistics, Hacettepe University Faculty of Science, Ankara, Turkey.

出版信息

J Clin Med Res. 2014 Feb;6(1):30-5. doi: 10.4021/jocmr1642w. Epub 2013 Dec 13.

DOI:10.4021/jocmr1642w
PMID:24400029
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3881987/
Abstract

BACKGROUND

Although breast cancer surgery is regarded as a "clean" surgery, surgical site infection (SSI) rates are higher than expected. There is no consensus regarding the use of antibiotic prophylaxis in elective breast surgery. The nationwide survey was conducted to determine the trend of antibiotic prophylaxis in breast cancer among Turkish surgeons.

METHODS

The survey was sent to surgeons who are member of Turkish Surgical Association (TSA) via e-mail from TSA web address. A 15 item web-based survey consisted of surgeon demographics and the use of prophylactic antibiotic in patients with risk factors related to SSI.

RESULTS

The number of completed questionnaires was 245. The most common antibiotic used was first generation of cephalosporins. A majority of respondents indicated that prophylaxis was preferred in patients with high risk of SSI including preoperative chemotherapy or radiotherapy, older age, diabetes mellitus, immunodeficiency, immediate reconstruction (P < 0.05). However, the use of drain did not significantly influence antibiotic prophylaxis (P = 0.091).

CONCLUSIONS

The use of prophylactic antibiotic was strongly dependent on the presence of some risk factors; however, the variation in current practice regarding antibiotic prophylaxis demonstrated a lack of its effect on preventing SSI after breast cancer surgery.

摘要

背景

尽管乳腺癌手术被视为“清洁”手术，但手术部位感染（SSI）发生率高于预期。对于择期乳腺癌手术中预防性使用抗生素尚无共识。开展全国性调查以确定土耳其外科医生在乳腺癌治疗中预防性使用抗生素的趋势。

方法

通过土耳其外科协会（TSA）网站地址以电子邮件方式向TSA成员外科医生发送调查问卷。一份基于网络的包含15项内容的调查问卷，涵盖外科医生人口统计学信息以及在具有与SSI相关危险因素的患者中预防性使用抗生素的情况。

结果

完成问卷的数量为245份。最常用的抗生素是第一代头孢菌素。大多数受访者表示，在具有SSI高风险的患者中更倾向于预防性使用抗生素，这些风险因素包括术前化疗或放疗、年龄较大、糖尿病、免疫缺陷、即刻乳房重建（P < 0.05）。然而，放置引流管对预防性使用抗生素并无显著影响（P = 0.091）。

结论

预防性使用抗生素很大程度上取决于某些风险因素的存在；然而，目前在预防性使用抗生素方面的实践差异表明其对预防乳腺癌手术后SSI缺乏效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/804d/3881987/c755ab662871/jocmr-06-30-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/804d/3881987/e45f48de3457/jocmr-06-30-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/804d/3881987/c755ab662871/jocmr-06-30-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/804d/3881987/e45f48de3457/jocmr-06-30-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/804d/3881987/c755ab662871/jocmr-06-30-g002.jpg

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National practice patterns in preoperative and postoperative antibiotic prophylaxis in breast procedures requiring drains: survey of the American Society of Breast Surgeons.
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