Department of Veterinary Medicine, University of Bari, Valenzano, Italy.
PLoS One. 2014 Jan 6;9(1):e85220. doi: 10.1371/journal.pone.0085220. eCollection 2014.
An outbreak of canine infectious respiratory disease (CIRD) associated to canine pneumovirus (CnPnV) infection is reported. The outbreak occurred in a shelter of the Apulia region and involved 37 out of 350 dogs that displayed cough and/or nasal discharge with no evidence of fever. The full-genomic characterisation showed that the causative agent (strain Bari/100-12) was closely related to CnPnVs that have been recently isolated in the USA, as well as to murine pneumovirus, which is responsible for respiratory disease in mice. The present study represents a useful contribution to the knowledge of the pathogenic potential of CnPnV and its association with CIRD in dogs. Further studies will elucidate the pathogenicity and epidemiology of this novel pneumovirus, thus addressing the eventual need for specific vaccines.
现报告一起与犬呼肠孤病毒（CnPnV）感染相关的犬传染性呼吸道疾病（CIRD）暴发。该起暴发发生在普利亚地区的一个收容所，涉及 350 只狗中的 37 只，这些狗表现出咳嗽和/或鼻分泌物，但没有发热的证据。全基因组特征表明，病原体（菌株 Bari/100-12）与最近在美国分离的 CnPnVs 以及引起小鼠呼吸道疾病的鼠呼肠孤病毒密切相关。本研究为了解 CnPnV 的致病潜力及其与犬 CIRD 的关系提供了有用的贡献。进一步的研究将阐明这种新型呼肠孤病毒的致病性和流行病学，从而解决对特定疫苗的潜在需求。
