*Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, D-13125 Berlin-Buch, Germany.
Clin Sci (Lond). 2014 Apr;126(8):529-36. doi: 10.1042/CS20130307.
A decade ago, the (P)RR [(pro)renin receptor] was discovered and depicted as a potential activator of the tissue renin-angiotensin system. For this reason, the role of the (P)RR in cardiovascular diseases and diabetes has been particularly studied. However, the discovery of embryonic lethality after (P)RR gene deletion in mouse and zebrafish paved the way for additional roles of (P)RR in cell homoeostasis. Indeed, the (P)RR has been shown to associate with vacuolar H+-ATPase, hence its other name ATP6ap2. Developmental studies in Xenopus and Drosophila have revealed an essential role of this association to promote the canonical and non-canonical Wnt signalling pathways, whereas studies with tissue-specific gene deletion have pointed out a role in autophagy. The present review aims to summarize recent findings on the cellular functions of (P)RR emerging from various mutated and transgenic animal models.
十年前，(P)RR [(前胰蛋白酶受体)]被发现，并被描绘为组织肾素-血管紧张素系统的潜在激活物。出于这个原因，(P)RR 在心血管疾病和糖尿病中的作用已经得到了特别的研究。然而，在小鼠和斑马鱼中敲除 (P)RR 基因后发现胚胎致死性，为 (P)RR 在细胞内稳态中的其他作用铺平了道路。事实上，(P)RR 已被证明与液泡 H+-ATP 酶相关，因此它还有另一个名字 ATP6ap2。在非洲爪蟾和果蝇中的发育研究揭示了这种关联对于促进经典和非经典 Wnt 信号通路的重要作用，而组织特异性基因敲除的研究则指出了其在自噬中的作用。本综述旨在总结来自各种突变和转基因动物模型的关于 (P)RR 细胞功能的最新发现。
