可溶性间皮素相关蛋白是否是胸膜间皮瘤的一线预测标志物？一项针对接触石棉的意大利工人的前瞻性研究。

Is soluble mesothelin-related protein an upfront predictive marker of pleural mesothelioma? A prospective study on Italian workers exposed to asbestos.

机构信息

Epidemiology, Biostatistics and Clinical Trials, IRCCS AOU San Martino - IST-Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy.

出版信息

Oncology. 2014;86(1):33-43. doi: 10.1159/000355687. Epub 2013 Dec 21.

DOI:10.1159/000355687

PMID:24401539

Abstract

OBJECTIVE

Soluble mesothelin-related peptide (SMRP) may be useful in the diagnosis and detection of early stage mesothelioma. We investigated the SMRP upfront predictive role for mesothelioma in asbestos-exposed workers.

METHODS

A total of 1,715 subjects underwent a first visit and were invited for a follow-up after 1 and 2 years, with a clinical examination and blood sampling. SMRP was measured by an ELISA assay.

RESULTS

Median SMRP at the first visit was 0.45 [interquartile range (IQR) i.e. 25th-75th percentile: 0.30-0.67 nmol/l]. In all, 1,676 subjects (97.8%) were followed up for a median period of 47.1 months. SMRP was measured at the first visit and at both follow-up visits in 1,536 subjects. At follow-up, 3 subjects were diagnosed with an epithelioid mesothelioma. In these cases, SMRP at the first visit ranged from 0.17 to 0.52 nmol/l. Malignant pleural mesothelioma was diagnosed 9-17 months after the last SMRP evaluation. No SMRP variation was observed during the follow-up. Other 61 miscellaneous cancers were diagnosed (median SMRP at first visit: 0.50 nmol/l, IQR: 0.34-0.71 nmol/l).

CONCLUSIONS

Our results did not support the usefulness of SMRP as an early marker for the detection of the disease for a time interval of 1 year.

摘要

目的

可溶性间皮素相关肽（SMRP）可用于间皮瘤的诊断和早期检测。我们研究了 SMRP 在接触石棉的工人中对间皮瘤的早期预测作用。

方法

共有 1715 名受试者进行了首次就诊，并在 1 年和 2 年后被邀请进行随访，包括临床检查和血液采样。SMRP 通过 ELISA 测定进行测量。

结果

首次就诊时的 SMRP 中位数为 0.45[四分位间距（IQR），即 25-75 分位数：0.30-0.67 nmol/l]。共有 1676 名受试者（97.8%）接受了中位数为 47.1 个月的随访。1536 名受试者在首次就诊和两次随访时均测量了 SMRP。在随访中，3 名患者被诊断为上皮样间皮瘤。在这些病例中，首次就诊时的 SMRP 范围为 0.17 至 0.52 nmol/l。恶性胸膜间皮瘤在最后一次 SMRP 评估后 9-17 个月被诊断出来。在随访期间未观察到 SMRP 变化。其他 61 种杂类癌症被诊断出（首次就诊时的 SMRP 中位数：0.50 nmol/l，IQR：0.34-0.71 nmol/l）。