早发性阿尔茨海默病临床亚型中的脑脊液生物标志物
Cerebrospinal fluid biomarkers in clinical subtypes of early-onset Alzheimer's disease.
作者信息
Teng Edmond, Yamasaki Tritia R, Tran Michelle, Hsiao Julia J, Sultzer David L, Mendez Mario F
机构信息
Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Calif., USA.
出版信息
Dement Geriatr Cogn Disord. 2014;37(5-6):307-14. doi: 10.1159/000355555. Epub 2013 Dec 31.
Abstract
BACKGROUND/AIMS: Accurate diagnosis of sporadic early-onset Alzheimer's disease (EOAD) can be challenging, and cerebrospinal fluid (CSF) biomarkers may assist in this process. We compared CSF indices between three EOAD subtypes: amnestic, logopenic progressive aphasia (LPA), and posterior cortical atrophy (PCA).
METHODS
We identified 21 amnestic EOAD, 20 LPA, and 12 PCA patients with CSF data, which included amyloid β1-42 (Aβ42), total tau (t-tau), phospho-tau181 (p-tau), and Aβ42/t-tau index (ATI) levels.
RESULTS
Aβ42 and ATI levels were similar across groups, but t-tau and p-tau levels were significantly lower in PCA patients.
CONCLUSIONS
The Aβ42 and ATI data confirm the commonality of the Aβ pathology in EOAD. The lower tau indices in PCA patients may reflect differences in the distribution of neurofibrillary tangles or rates of neurodegeneration.
摘要
背景/目的：散发性早发型阿尔茨海默病（EOAD）的准确诊断具有挑战性，脑脊液（CSF）生物标志物可能有助于这一过程。我们比较了三种EOAD亚型（遗忘型、语义性进行性失语（LPA）和后皮质萎缩（PCA））之间的脑脊液指标。
方法
我们确定了21例遗忘型EOAD、20例LPA和12例PCA患者的脑脊液数据，其中包括淀粉样β1-42（Aβ42）、总tau蛋白（t-tau）、磷酸化tau181（p-tau）和Aβ42/t-tau指数（ATI）水平。
结果
各组间Aβ42和ATI水平相似，但PCA患者的t-tau和p-tau水平显著较低。
结论
Aβ42和ATI数据证实了EOAD中Aβ病理的共性。PCA患者较低的tau指数可能反映了神经原纤维缠结分布或神经退行性变率的差异。
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