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戊二醛灭活百日咳疫苗:安全性试验中的一种安全疫苗。

Glutaraldehyde inactivated pertussis vaccine: a safe vaccine in the innocuity test.

作者信息

Gupta R K, Sharma S B, Ahuja S, Saxena S N

出版信息

Vaccine. 1987 Jun;5(2):102-4. doi: 10.1016/0264-410x(87)90054-5.

DOI:10.1016/0264-410x(87)90054-5
PMID:2440196
Abstract

The adsorbed diphtheria-pertussis-tetanus (DPT) vaccine containing glutaraldehyde inactivated pertussis vaccine passed the innocuity test only after one month's storage of the preparation at 4-8 degrees C when the adsorbed DPT vaccine containing pertussis vaccine inactivated by heat, formaldehyde, thimerosal or acetone did not pass the test. The adsorbed DPT vaccine became innocuous when it was stored at 4-8 degrees C. The innocuity test was passed more easily in guinea pigs than in mice.

摘要

含有戊二醛灭活百日咳疫苗的吸附白喉-百日咳-破伤风(DPT)疫苗,在制剂于4-8℃储存一个月后通过了无毒性试验,而含有经热、甲醛、硫柳汞或丙酮灭活的百日咳疫苗的吸附DPT疫苗未通过该试验。吸附DPT疫苗在4-8℃储存时变得无毒。无毒性试验在豚鼠中比在小鼠中更容易通过。

相似文献

1
Glutaraldehyde inactivated pertussis vaccine: a safe vaccine in the innocuity test.戊二醛灭活百日咳疫苗:安全性试验中的一种安全疫苗。
Vaccine. 1987 Jun;5(2):102-4. doi: 10.1016/0264-410x(87)90054-5.
2
Comparative stabilities of glutaraldehyde & heat inactivated pertussis vaccine components of adsorbed DPT vaccine with different preservatives.吸附百白破疫苗中不同防腐剂条件下戊二醛和热灭活百日咳疫苗成分的稳定性比较
Indian J Med Res. 1992 Jan;95:8-11.
3
The effects of different inactivating agents on the potency, toxicity and stability of pertussis vaccine.不同灭活剂对百日咳疫苗效力、毒性及稳定性的影响。
J Biol Stand. 1987 Jan;15(1):87-98. doi: 10.1016/0092-1157(87)90020-5.
4
Glutaraldehyde inactivated pertussis vaccine: a less histamine sensitizing vaccine.
J Biol Stand. 1987 Apr;15(2):159-64. doi: 10.1016/0092-1157(87)90038-2.
5
Effects of elevated temperatures on the opacity and toxicity of pertussis vaccines manufactured with different inactivating agents.高温对使用不同灭活剂生产的百日咳疫苗的不透明度和毒性的影响。
Vaccine. 1986 Sep;4(3):185-90. doi: 10.1016/0264-410x(86)90008-3.
6
Studies on the optimal conditions for inactivation of Bordetella pertussis organisms with glutaraldehyde for preparation of a safe and potent pertussis vaccine.关于用戊二醛灭活百日咳博德特氏菌制备安全高效百日咳疫苗的最佳条件的研究。
Vaccine. 1988 Dec;6(6):491-6. doi: 10.1016/0264-410x(88)90099-0.
7
Quadruple vaccines containing pertussis and poliomyelitis vaccines.含有百日咳和脊髓灰质炎疫苗的四联疫苗。
Health Lab Sci. 1978 Jul;15(3):138-43.
8
Role of whole-cell pertussis vaccine in severe local reactions to the preschool (fifth) dose of diphtheria-pertussis-tetanus vaccine.全细胞百日咳疫苗在白喉-百日咳-破伤风疫苗学龄前(第五剂)严重局部反应中的作用
CMAJ. 1994 Jan 1;150(1):29-35.
9
Pertussis vaccine: reactivity in animal and man.百日咳疫苗:在动物和人类中的反应性。
Dev Biol Stand. 1977;34:207-11.
10
Comparative studies on pertussis vaccine batches inactivated with glutaraldehyde, beta-propiolactone, formaldehyde or thiomersal.
Arch Roum Pathol Exp Microbiol. 1979 Jul-Dec;38(3-4):299-308.

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Study on Toxicity Reduction and Potency Induction in Whole-cell Pertussis Vaccine by Developing a New Optimal Inactivation Condition Processed on Bordetella pertussis.通过开发针对百日咳博德特氏菌的新的最佳灭活条件来降低全细胞百日咳疫苗毒性并诱导效力的研究。
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