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戊二醛灭活百日咳疫苗:安全性试验中的一种安全疫苗。

Glutaraldehyde inactivated pertussis vaccine: a safe vaccine in the innocuity test.

作者信息

Gupta R K, Sharma S B, Ahuja S, Saxena S N

出版信息

Vaccine. 1987 Jun;5(2):102-4. doi: 10.1016/0264-410x(87)90054-5.

Abstract

The adsorbed diphtheria-pertussis-tetanus (DPT) vaccine containing glutaraldehyde inactivated pertussis vaccine passed the innocuity test only after one month's storage of the preparation at 4-8 degrees C when the adsorbed DPT vaccine containing pertussis vaccine inactivated by heat, formaldehyde, thimerosal or acetone did not pass the test. The adsorbed DPT vaccine became innocuous when it was stored at 4-8 degrees C. The innocuity test was passed more easily in guinea pigs than in mice.

摘要

含有戊二醛灭活百日咳疫苗的吸附白喉-百日咳-破伤风(DPT)疫苗,在制剂于4-8℃储存一个月后通过了无毒性试验,而含有经热、甲醛、硫柳汞或丙酮灭活的百日咳疫苗的吸附DPT疫苗未通过该试验。吸附DPT疫苗在4-8℃储存时变得无毒。无毒性试验在豚鼠中比在小鼠中更容易通过。

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