Gupta R K, Saxena S N, Sharma S B, Ahuja S
Biological Standardization & Quality Control Division, Central Research Institute, Kasauli.
Indian J Med Res. 1992 Jan;95:8-11.
The stability of pertussis component (glutaraldehyde or heat inactivated pertussis vaccine) of the adsorbed diphtheria-pertussis-tetanus (DPT) vaccine preserved in thiomersal or benzethonium chloride was studied at 4-8 degrees C and 35 degrees C for 30 days. The potency of pertussis component of adsorbed DPT vaccine preserved with benzethonium chloride was lower than that preserved with thiomersal. After the initial loss of potency of pertussis component in the benzethonium chloride during blending, the stability of potency of pertussis component at 4-8 degrees C and 35 degrees C for 30 days was similar for vaccines preserved with either benzethonium chloride or thiomersal. The stability of both types of pertussis components inactivated with glutaraldehyde or heat was also similar at both the temperatures for 30 days.
在4-8摄氏度和35摄氏度下，对保存在硫柳汞或苄索氯铵中的吸附型白喉-百日咳-破伤风（DPT）疫苗的百日咳成分（戊二醛或热灭活百日咳疫苗）稳定性进行了30天的研究。用苄索氯铵保存的吸附型DPT疫苗的百日咳成分效力低于用硫柳汞保存的。在混合过程中苄索氯铵保存的百日咳成分初始效力损失后，在4-8摄氏度和35摄氏度下保存30天，用苄索氯铵或硫柳汞保存的疫苗百日咳成分效力稳定性相似。在这两个温度下30天，两种用戊二醛或热灭活的百日咳成分的稳定性也相似。
