Departments of Psychiatry and Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California.
Obstet Gynecol. 2014 Feb;123(2 Pt 1):263-270. doi: 10.1097/AOG.0000000000000092.
To examine whether a first abortion increases risk of mental health disorders compared with a first childbirth with and without considering prepregnancy mental health and adverse exposures, childhood economic status, miscarriage history, age at first abortion or childbirth, and race or ethnicity.
A cohort study compared rates of mental disorders (anxiety, mood, impulse-control, substance use, eating disorders, and suicidal ideation) among 259 women postabortion and 677 women postchildbirth aged 18-42 years at the time of interview from The National Comorbidity Survey-Replication.
The percentage of women with no, one, two, and three or more mental health disorders before their first abortion was 37.8%, 19.7%, 15.2%, and 27.3% and before their first childbirth was 57.9%, 19.6%, 9.2%, and 13.3%, respectively, indicating that women in the abortion group had more prior mental health disorders than women in the childbirth group (P<.001). Although in unadjusted Cox proportional hazard models, abortion compared with childbirth was associated with statistically significant higher hazards of postpregnancy mental health disorders, associations were reduced and became nonstatistically significant for five disorders after adjusting for the aforementioned factors. Hazard ratios and associated 95% confidence intervals dropped from 1.52 (1.08-2.15) to 1.12 (0.87-1.46) for anxiety disorders; from 1.56 (1.23-1.98) to 1.18 (0.88-1.56) for mood disorders; from 1.62 (1.02-2.57) to 1.10 (0.75-1.62) for impulse-control disorders; from 2.53 (1.09-5.86) to 1.82 (0.63-5.25) for eating disorders; and from 1.62 (1.09-2.40) to 1.25 (0.88-1.78) for suicidal ideation. Only the relationship between abortion and substance use disorders remained statistically significant, although the hazard ratio dropped from 3.05 (1.94-4.79) to 2.30 (1.35-3.92).
After accounting for confounding factors, abortion was not a statistically significant predictor of subsequent anxiety, mood, impulse-control, and eating disorders or suicidal ideation. LEVEL OF EVEDIENCE: II.
探讨首次堕胎是否会增加心理健康障碍的风险,与首次分娩相比,并考虑到孕前心理健康和不良暴露、儿童期经济状况、流产史、首次堕胎或分娩年龄以及种族或民族。
一项队列研究比较了在接受采访时年龄在 18-42 岁的 259 名堕胎后妇女和 677 名分娩后妇女的精神障碍(焦虑、情绪、冲动控制、物质使用、饮食障碍和自杀意念)发生率,来自国家共病调查-复制。
首次堕胎前无、一、二、三种或更多种心理健康障碍的妇女百分比分别为 37.8%、19.7%、15.2%和 27.3%,首次分娩前分别为 57.9%、19.6%、9.2%和 13.3%,表明堕胎组的妇女比分娩组的妇女有更多的先前心理健康障碍(P<.001)。尽管在未调整的 Cox 比例风险模型中,与分娩相比,堕胎与产后心理健康障碍的发生具有统计学意义上的更高风险相关,但在调整上述因素后,五种障碍的关联减少且不再具有统计学意义。焦虑障碍的风险比和相关 95%置信区间从 1.52(1.08-2.15)降至 1.12(0.87-1.46);心境障碍从 1.56(1.23-1.98)降至 1.18(0.88-1.56);冲动控制障碍从 1.62(1.02-2.57)降至 1.10(0.75-1.62);饮食障碍从 2.53(1.09-5.86)降至 1.82(0.63-5.25);自杀意念从 1.62(1.09-2.40)降至 1.25(0.88-1.78)。只有堕胎与物质使用障碍之间的关系仍然具有统计学意义,尽管风险比从 3.05(1.94-4.79)降至 2.30(1.35-3.92)。
在考虑混杂因素后,堕胎不是随后发生焦虑、情绪、冲动控制和饮食障碍或自杀意念的统计学显著预测因子。
II 级。