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Pertussis toxin inhibits somatostatin-induced K+ conductance in human pituitary tumor cells.

作者信息

Yamashita N, Kojima I, Shibuya N, Ogata E

出版信息

Am J Physiol. 1987 Jul;253(1 Pt 1):E28-32. doi: 10.1152/ajpendo.1987.253.1.E28.

DOI:10.1152/ajpendo.1987.253.1.E28
PMID:2440314
Abstract

The effect of pertussis toxin on somatostatin-induced K+ current was examined in dissociated human pituitary tumor cells obtained from two acromegalic patients. Somatostatin-induced hyperpolarization or K+ current was observed in 20 of 23 cells in adenoma 1 and 10 of 11 cells in adenoma 2. After treatment with pertussis toxin for 24 h, these responses were completely suppressed (0/14 in adenoma 1, 0/10 in adenoma 2). Spontaneous action potentials, K+, Na+, and Ca2+ currents were well preserved after pertussis toxin treatment. When crude membrane fraction was incubated with [32P]NAD, a 41K protein was ADP-ribosylated by pertussis toxin. Hormone release was inhibited by somatostatin and this inhibition was blocked by pertussis toxin treatment.

摘要

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