Drozd Michael, Witte Klaus
G Ital Nefrol. 2013 Jul-Aug;30(4).
Over recent years the cardiovascular safety of calcium supplementation, taken by millions on a daily basis, has raised concerns. Despite the borderline benefit of calcium supplementation in regards to fracture risk reduction, osteoporosis guidelines continue to advocate daily calcium supplementation assuming that calcium does no harm. However, reanalysis of large randomised controlled trials (RCTs) and observational studies consistently show a modest, but significant increased cardiovascular risk in healthy individuals taking calcium supplementation. The aim of this review is summarise recent data demonstrating elevated cardiovascular risk possibly attributable to oral calcium supplementation in healthy individuals.
近年来，每天有数百万人服用的补钙产品的心血管安全性引发了人们的关注。尽管补钙在降低骨折风险方面的益处并不显著，但骨质疏松症指南仍继续提倡每日补钙，认为钙没有危害。然而，对大型随机对照试验（RCT）和观察性研究的重新分析一致表明，健康个体服用补钙产品会使心血管风险有适度但显著的增加。本综述的目的是总结近期数据，这些数据表明健康个体口服补钙产品可能会增加心血管风险。
