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Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.

作者信息

Herzyk P, Beveridge A, Neidle S

出版信息

Biochem Biophys Res Commun. 1987 Jun 30;145(3):1356-61. doi: 10.1016/0006-291x(87)91587-7.

DOI:10.1016/0006-291x(87)91587-7
PMID:2440430
Abstract

The low-energy conformations of 3'-azido-3'-deoxy-thymidine, (AZT), an inhibitor of retroviral reverse transcriptase, have been studied by molecular mechanics techniques. A force-field has been developed for the azido group by quantum-mechanical methods, and used in the analysis. The global low-energy structure of AZT has C3'-endo sugar pucker, an anti glycosidic angle, and a g+ C4'-C5' conformation. It is concluded that the AZT molecule has conformational properties that are very similar to those of standard deoxypyrimidines.

摘要

相似文献

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Conformational properties of 3'-azido-3'deoxy-thymidine (AZT), an inhibitor of HIV reverse transcriptase.
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2
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引用本文的文献

1
Correlation between preferred sugar ring conformation and activity of nucleoside analogues against human immunodeficiency virus.核苷类似物对人免疫缺陷病毒的活性与优选糖环构象之间的相关性。
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