Gurskaya G V, Bochkarev A V, Zdanov A S, Papchikhin A V, Purygin P P, Krayevsky A A
V.A. Engelhardt Institute of Molecular Biology, USSR Academy of Sciences, Moscow.
FEBS Lett. 1990 Jun 4;265(1-2):63-6. doi: 10.1016/0014-5793(90)80884-l.
2',3'-Lyxoanhydrothymidine (LAT), a conformationally restricted inhibitor of retroviral reverse transcriptases, has been studied by X-ray analysis. The unit cell contains two crystallographically independent molecules A and B. Their sugar moieties have an identical structure: an 04'-endo pucker of the furanose cycle and a trans conformation about the exocyclic C4'-C5' bond. The conformations of A and B molecules differ with respect to the N-glycosidic bond: chi A(04 'Cl' N1C2) = -121.9 degrees which is typical of a common anti conformation whereas chi B (04'Cl'N1C2) = 121.2 degrees corresponds to a rare high-syn conformation. All the conformation properties of LAT molecules stem from the presence of an epoxide cycle in their molecules.
2',3'-异阿拉伯糖型脱水胸苷（LAT）是一种对逆转录病毒逆转录酶具有构象限制作用的抑制剂，已通过X射线分析进行了研究。晶胞包含两个晶体学独立的分子A和B。它们的糖部分具有相同的结构：呋喃糖环为04'-内型构象，环外C4'-C5'键为反式构象。A和B分子的构象在N-糖苷键方面有所不同：χA(04'Cl'N1C2) = -121.9°，这是常见反式构象的典型特征，而χB(04'Cl'N1C2) = 121.2°则对应于罕见的高顺式构象。LAT分子的所有构象性质均源于其分子中环氧环的存在。
