应用动态对比增强（DCE）MRI 对动脉粥样硬化斑块炎症进行定量分析。
Atherosclerotic plaque inflammation quantification using dynamic contrast-enhanced (DCE) MRI.
机构信息
Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University, Beijing 100084, China;
Department of Radiology, University of Washington, Seattle, Washington, USA.
出版信息
Quant Imaging Med Surg. 2013 Dec;3(6):298-301. doi: 10.3978/j.issn.2223-4292.2013.12.01.
Abstract
Inflammation plays an important role in atherosclerosis. Given the increasing interest in using in-vivo imaging methods to study the physiology and treatment effects in atherosclerosis, noninvasive intraplaque inflammation quantitative method is needed. Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) has been proposed and validated to quantitatively characterize atherosclerotic plaque inflammation. Recent studies have optimized the imaging protocol, pharmacokinetic modeling techniques. All of these technical advances further promoted DCE-MRI to clinical investigations in plaque risk assessment and therapeutic response monitor. Although larger clinical studies are still needed, DCE-MRI has been proven to be a promising tool to reveal more about intraplaque inflammation by in vivo quantitative inflammation imaging.
摘要
炎症在动脉粥样硬化中起着重要作用。鉴于人们越来越感兴趣地使用体内成像方法来研究动脉粥样硬化中的生理学和治疗效果，因此需要一种非侵入性的斑块内炎症定量方法。动态对比增强（DCE）磁共振成像（MRI）已被提出并验证可定量表征动脉粥样硬化斑块炎症。最近的研究已经优化了成像方案、药代动力学建模技术。所有这些技术进步都进一步推动了 DCE-MRI 在斑块风险评估和治疗反应监测的临床研究中。虽然还需要更大规模的临床研究，但 DCE-MRI 已被证明是一种很有前途的工具，通过体内定量炎症成像来揭示更多关于斑块内炎症的信息。
相似文献
1
Atherosclerotic plaque inflammation quantification using dynamic contrast-enhanced (DCE) MRI.
Quant Imaging Med Surg. 2013 Dec;3(6):298-301. doi: 10.3978/j.issn.2223-4292.2013.12.01.
2
Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques.
NMR Biomed. 2015 Oct;28(10):1304-14. doi: 10.1002/nbm.3369. Epub 2015 Aug 30.
3
Dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) of atherosclerotic plaque angiogenesis.
Angiogenesis. 2010 Jun;13(2):87-99. doi: 10.1007/s10456-010-9172-2. Epub 2010 Jun 6.
4
Combined PET/DCE-MRI in a Rabbit Model of Atherosclerosis: Integrated Quantification of Plaque Inflammation, Permeability, and Burden During Treatment With a Leukotriene A4 Hydrolase Inhibitor.
JACC Cardiovasc Imaging. 2018 Feb;11(2 Pt 2):291-301. doi: 10.1016/j.jcmg.2017.11.030.
5
Dynamic Contrast-Enhanced MRI to Study Atherosclerotic Plaque Microvasculature.
Curr Atheroscler Rep. 2016 Jun;18(6):33. doi: 10.1007/s11883-016-0583-4.
6
Imaging of Carotid Plaque Neovascularization by Contrast-Enhanced Ultrasound and Dynamic Contrast-Enhanced Magnetic Resonance Imaging.
Cerebrovasc Dis. 2019;48(3-6):140-148. doi: 10.1159/000504042. Epub 2019 Oct 29.
7
Progression of experimental lesions of atherosclerosis: assessment by kinetic modeling of black-blood dynamic contrast-enhanced MRI.
Magn Reson Med. 2013 Jun;69(6):1712-20. doi: 10.1002/mrm.24415. Epub 2012 Jul 24.
8
Vessel wall and adventitial DCE-MRI parameters demonstrate similar correlations with carotid plaque microvasculature on histology.
J Magn Reson Imaging. 2017 Oct;46(4):1053-1059. doi: 10.1002/jmri.25648. Epub 2017 Feb 2.
9
Evaluation of carotid plaque vulnerability in vivo: Correlation between dynamic contrast-enhanced MRI and MRI-modified AHA classification.
J Magn Reson Imaging. 2017 Sep;46(3):870-876. doi: 10.1002/jmri.25637. Epub 2017 Jan 24.
10
Neovascularization in Vertebral Artery Atheroma-A Dynamic Contrast-Enhanced Magnetic Resonance Imaging-Based Comparative Study in Patients with Symptomatic and Asymptomatic Carotid Artery Disease.
J Stroke Cerebrovasc Dis. 2018 Sep;27(9):2505-2512. doi: 10.1016/j.jstrokecerebrovasdis.2018.05.011. Epub 2018 May 24.
引用本文的文献
1
Advanced Imaging Techniques for Atherosclerosis and Cardiovascular Calcification in Animal Models.
J Cardiovasc Dev Dis. 2024 Dec 22;11(12):410. doi: 10.3390/jcdd11120410.
2
Role of plaque inflammation in symptomatic carotid stenosis.
Front Neurol. 2023 Jan 24;14:1086465. doi: 10.3389/fneur.2023.1086465. eCollection 2023.
3
Disposable point-of-care portable perfusion phantom for quantitative DCE-MRI.
Med Phys. 2022 Jan;49(1):271-281. doi: 10.1002/mp.15372. Epub 2021 Dec 10.
4
Ultra-high resolution, 3-dimensional magnetic resonance imaging of the atherosclerotic vessel wall at clinical 7T.
PLoS One. 2020 Dec 14;15(12):e0241779. doi: 10.1371/journal.pone.0241779. eCollection 2020.
5
Symptomatic Carotid Plaques Demonstrate Less Leaky Plaque Microvasculature Compared With the Contralateral Side: A Dynamic Contrast-Enhanced Magnetic Resonance Imaging Study.
J Am Heart Assoc. 2019 Apr 16;8(8):e011832. doi: 10.1161/JAHA.118.011832.
6
Microvasculature and intraplaque hemorrhage in atherosclerotic carotid lesions: a cardiovascular magnetic resonance imaging study.
J Cardiovasc Magn Reson. 2019 Mar 4;21(1):15. doi: 10.1186/s12968-019-0524-9.
7
High-resolution vessel wall MRI for the evaluation of intracranial atherosclerotic disease.
Neuroradiology. 2017 Dec;59(12):1193-1202. doi: 10.1007/s00234-017-1925-9. Epub 2017 Sep 23.
8
Assessment of therapeutic response in Crohn's disease using quantitative dynamic contrast enhanced MRI (DCE-MRI) parameters: A preliminary study.
Medicine (Baltimore). 2017 Aug;96(32):e7759. doi: 10.1097/MD.0000000000007759.
9
Can Dynamic Contrast-Enhanced MRI (DCE-MRI) and Diffusion-Weighted MRI (DW-MRI) Evaluate Inflammation Disease: A Preliminary Study of Crohn's Disease.
Medicine (Baltimore). 2016 Apr;95(14):e3239. doi: 10.1097/MD.0000000000003239.
10
Three-dimensional dynamic contrast-enhanced MRI for the accurate, extensive quantification of microvascular permeability in atherosclerotic plaques.
NMR Biomed. 2015 Oct;28(10):1304-14. doi: 10.1002/nbm.3369. Epub 2015 Aug 30.
本文引用的文献
1
Assessment of subclinical atherosclerosis and intraplaque neovascularization using quantitative contrast-enhanced ultrasound in patients with familial hypercholesterolemia.
Atherosclerosis. 2013 Nov;231(1):107-13. doi: 10.1016/j.atherosclerosis.2013.08.040. Epub 2013 Sep 11.
2
Combined 18F-FDG PET-CT and DCE-MRI to assess inflammation and microvascularization in atherosclerotic plaques.
Stroke. 2013 Dec;44(12):3568-70. doi: 10.1161/STROKEAHA.113.003140. Epub 2013 Oct 10.
3
The complementary roles of dynamic contrast-enhanced MRI and 18F-fluorodeoxyglucose PET/CT for imaging of carotid atherosclerosis.
Eur J Nucl Med Mol Imaging. 2013 Dec;40(12):1884-93. doi: 10.1007/s00259-013-2518-4. Epub 2013 Aug 14.
4
SHILO, a novel dual imaging approach for simultaneous HI-/LOw temporal (Low-/Hi-spatial) resolution imaging for vascular dynamic contrast enhanced cardiovascular magnetic resonance: numerical simulations and feasibility in the carotid arteries.
J Cardiovasc Magn Reson. 2013 May 24;15(1):42. doi: 10.1186/1532-429X-15-42.
5
Adventitial perfusion and intraplaque hemorrhage: a dynamic contrast-enhanced MRI study in the carotid artery.
Stroke. 2013 Apr;44(4):1031-6. doi: 10.1161/STROKEAHA.111.000435. Epub 2013 Mar 7.
6
Dynamic contrast-enhanced MR imaging of carotid atherosclerotic plaque: model selection, reproducibility, and validation.
Radiology. 2013 Jan;266(1):271-9. doi: 10.1148/radiol.12120499. Epub 2012 Nov 14.
7
Regression of inflammation in atherosclerosis by the LXR agonist R211945: a noninvasive assessment and comparison with atorvastatin.
JACC Cardiovasc Imaging. 2012 Aug;5(8):819-28. doi: 10.1016/j.jcmg.2011.11.025.
8
Longitudinal MRI study on the natural history of carotid artery plaques in symptomatic patients.
PLoS One. 2012;7(7):e42472. doi: 10.1371/journal.pone.0042472. Epub 2012 Jul 31.
9
Progression of experimental lesions of atherosclerosis: assessment by kinetic modeling of black-blood dynamic contrast-enhanced MRI.
Magn Reson Med. 2013 Jun;69(6):1712-20. doi: 10.1002/mrm.24415. Epub 2012 Jul 24.
10
Temporal/spatial resolution improvement of in vivo DCE-MRI with compressed sensing-optimized FLASH.
Magn Reson Imaging. 2012 Jul;30(6):741-52. doi: 10.1016/j.mri.2012.02.001. Epub 2012 Mar 31.
Zotero 插件