用于定量 DCE-MRI 的一次性即时便携灌注体模。
Disposable point-of-care portable perfusion phantom for quantitative DCE-MRI.
机构信息
Interdisciplinary Engineering, University of Alabama, Birmingham, Alabama, USA.
Engineering and Innovative Technology Development, University of Alabama, Birmingham, Alabama, USA.
出版信息
Med Phys. 2022 Jan;49(1):271-281. doi: 10.1002/mp.15372. Epub 2021 Dec 10.
PURPOSE
To develop a disposable point-of-care portable perfusion phantom (DP4) and validate its clinical utility in a multi-institutional setting for quantitative dynamic contrast-enhanced magnetic resonance imaging (qDCE-MRI).
METHODS
The DP4 phantom was designed for single-use and imaged concurrently with a human subject so that the phantom data can be utilized as the reference to detect errors in qDCE-MRI measurement of human tissues. The change of contrast-agent concentration in the phantom was measured using liquid chromatography-mass spectrometry. The repeatability of the contrast enhancement curve (CEC) was assessed with five phantoms in a single MRI scanner. Five healthy human subjects were recruited to evaluate the reproducibility of qDCE-MRI measurements. Each subject was imaged concurrently with the DP4 phantom at two institutes using three 3T MRI scanners from three different vendors. Pharmacokinetic (PK) parameters in the regions of liver, spleen, pancreas, and paravertebral muscle were calculated based on the Tofts model (TM), extended Tofts model (ETM), and shutter speed model (SSM). The reproducibility of each PK parameter over three measurements was evaluated with the intraclass correlation coefficient (ICC) and compared before and after DP4-based error correction.
RESULTS
The contrast-agent concentration in the DP4 phantom was linearly increased over 10 min (0.17 mM/min, measurement accuracy: 96%) after injecting gadoteridol (100 mM) at a constant rate (0.24 ml/s, 4 ml). The repeatability of the CEC within the phantom was 0.997 when assessed by the ICC. The reproducibility of the volume transfer constant, K , was the highest of the PK parameters regardless of the PK models. The ICCs of K in the TM, ETM, and SSM before DP4-based error correction were 0.34, 0.39, and 0.72, respectively, while those increased to 0.93, 0.98, and 0.86, respectively, after correction.
CONCLUSIONS
The DP4 phantom is reliable, portable, and capable of significantly improving the reproducibility of qDCE-MRI measurements.
目的
开发一种一次性即时便携灌注体模（DP4），并在多中心环境中验证其在定量动态对比增强磁共振成像（qDCE-MRI）中的临床实用性。
方法
DP4 体模设计为一次性使用，与人体同时成像，以便将体模数据用作检测人体组织 qDCE-MRI 测量误差的参考。使用液相色谱-质谱法测量体模中对比剂浓度的变化。在单个 MRI 扫描仪中，使用五个体模评估对比增强曲线（CEC）的重复性。招募五名健康的人类受试者，以评估 qDCE-MRI 测量的重现性。每个受试者在两个研究所使用三台来自三个不同供应商的 3T MRI 扫描仪，与 DP4 体模同时成像。基于 Tofts 模型（TM）、扩展 Tofts 模型（ETM）和快门速度模型（SSM）计算肝脏、脾脏、胰腺和椎旁肌肉的药代动力学（PK）参数。使用组内相关系数（ICC）评估每个 PK 参数在三次测量中的重现性，并在 DP4 校正前后进行比较。
结果
在以 0.24ml/s（4ml）的恒定速率注入钆特醇（100mM）后，DP4 体模中的对比剂浓度在 10 分钟内线性增加（0.17mM/min，测量精度：96%）。通过 ICC 评估，体模内 CEC 的重复性为 0.997。在所有 PK 模型中，容积转移常数 K 的重现性最高。TM、ETM 和 SSM 中 K 的 ICC 在 DP4 校正前分别为 0.34、0.39 和 0.72，校正后分别增加到 0.93、0.98 和 0.86。
结论
DP4 体模可靠、便携，能够显著提高 qDCE-MRI 测量的重现性。
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