α-微管蛋白单克隆抗体TU-O1表位的定位
Location of the epitope for the alpha-tubulin monoclonal antibody TU-O1.
作者信息
Grimm M, Breitling F, Little M
出版信息
Biochim Biophys Acta. 1987 Jul 24;914(1):83-8. doi: 10.1016/0167-4838(87)90164-6.
PMID:2440481
Abstract
A cyanogen bromide peptide of pig brain alpha-tubulin with high reactivity to the monoclonal antibody TU-O1 has been isolated and identified. It corresponds to positions 37-154 of the alpha-tubulin sequence. A tryptic peptide within this region corresponding to positions 65-79 was also immunoreactive. Its relatively low reactivity, however, indicates that one or more important determinants are missing.
摘要
已分离并鉴定出猪脑α-微管蛋白的一种对单克隆抗体TU-O1具有高反应性的溴化氰肽。它对应于α-微管蛋白序列的第37至154位。该区域内对应于第65至79位的胰蛋白酶肽也具有免疫反应性。然而，其相对较低的反应性表明缺少一个或多个重要的决定簇。
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