Taquet H, Javoy-Agid F, Mauborgne A, Benoliel J J, Agid Y, Legrand J C, Hamon M, Cesselin F
Brain Res. 1987 May 12;411(1):178-82. doi: 10.1016/0006-8993(87)90697-4.
No significant alterations in the levels of Met-enkephalin-, Leu-enkephalin-, cholecystokinin- and substance P-like immunoreactive materials were found in 10 areas of postmortem brains from patients with progressive supranuclear palsy (PSP) when compared to controls. These results are at difference with the marked decrease in the levels of enkephalin-, cholecystokinin- and substance P-like immunoreactive materials previously reported in the basal ganglia of parkinsonian patients. Since PSP and Parkinson's disease are both characterized by a severe dopamine nigrostriatal deficit, these results suggest that the decreased brain peptide concentrations found in Parkinson's disease do not simply result from a dopaminergic neuronal loss.
与对照组相比，在进行性核上性麻痹（PSP）患者尸检大脑的10个区域中，未发现甲硫氨酸脑啡肽、亮氨酸脑啡肽、胆囊收缩素和P物质样免疫反应物质水平有显著变化。这些结果与先前报道的帕金森病患者基底节中脑啡肽、胆囊收缩素和P物质样免疫反应物质水平的显著降低不同。由于PSP和帕金森病都以严重的多巴胺黑质纹状体缺陷为特征，这些结果表明，帕金森病中发现的脑肽浓度降低并非仅仅由多巴胺能神经元丢失所致。
