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A comparative immunohistochemical study on striatal Met-enkephalin expression in Alzheimer's disease and in progressive supranuclear palsy.

作者信息

Matsumoto S, Goto S, Hirano A

机构信息

Bluestone Laboratory, Division of Neuropathology, Montefiore Medical Center, Bronx, NY 10467.

出版信息

Acta Neuropathol. 1990;81(1):74-7. doi: 10.1007/BF00662640.

DOI:10.1007/BF00662640
PMID:2085095
Abstract

Using a sensitive immunoperoxidase technique we examined Met-enkephalin (MEnk) expression in the striatum and globus pallidus external segment (GPe) from patients with Alzheimer's disease (AD) and with progressive supranuclear palsy (PSP). In AD patients strong MEnk-like immunoreactivity was persistent in the striatum showing so-called "striosomes". In addition, a number of typical "woolly fibers" were observed in the GPe. MEnk-positive striosomes were also visible in the striatum of PSP patients and were similar to those of normal controls and of AD patients. However, the MEnk-positive "woolly fibers" appearance was less well recognizable in the GPe from all the PSP patients examined.

摘要

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PROGRESSIVE SUPRANUCLEAR PALSY. A HETEROGENEOUS DEGENERATION INVOLVING THE BRAIN STEM, BASAL GANGLIA AND CEREBELLUM WITH VERTICAL GAZE AND PSEUDOBULBAR PALSY, NUCHAL DYSTONIA AND DEMENTIA.进行性核上性麻痹。一种涉及脑干、基底神经节和小脑的异质性变性，伴有垂直凝视和假性延髓麻痹、颈部肌张力障碍和痴呆。
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