Matsumoto Ryuji, Abe Takashige, Shinohara Nobuo, Murai Sachiyo, Maruyama Satoru, Tsuchiya Kunihiko, Nonomura Katsuya
Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Int J Urol. 2014 Jun;21(6):549-52. doi: 10.1111/iju.12388. Epub 2014 Jan 9.
To evaluate the association between the RENAL nephrometry score and annual growth rates of renal masses presumed to be renal cell carcinoma.
The current study included 47 renal tumors followed up for at least 12 months, of which 26 tumors were found to be pathologically proven renal cell carcinomas. Annual tumor growth rates were calculated from changes in the maximal diameter on computed tomography, and RENAL nephrometry scores were recorded on initial imaging by two senior urologists. The associations between clinical characteristics including the RENAL nephrometry score and annual growth rates were analyzed using a linear regression model.
The median tumor size at diagnosis was 1.7 cm (range 0.6-5.8). The median nephrometry score at diagnosis was 7 (range 4-10). Overall, the median tumor growth rate was 0.34 cm per year (range -0.19-2.0). Linear regression analysis showed that the annual tumor growth rate was associated with the RENAL nephrometry score (P < 0.0001), but it was independent of the age at diagnosis, sex and initial tumor size. In addition, the correlation between the RENAL nephrometry score and annual growth rate remained significant in the 26 pathologically proven renal cell carcinomas.
The RENAL nephrometry score is associated with the annual growth rate of renal masses. Our findings further support the association between the RENAL nephrometry score and tumor biology.
评估RENAL肾计量评分与疑似肾细胞癌的肾肿块年生长率之间的关联。
本研究纳入了47例随访至少12个月的肾肿瘤，其中26例经病理证实为肾细胞癌。根据计算机断层扫描上最大直径的变化计算肿瘤年生长率，并由两名资深泌尿外科医生在初始影像学检查时记录RENAL肾计量评分。使用线性回归模型分析包括RENAL肾计量评分在内的临床特征与年生长率之间的关联。
诊断时肿瘤的中位大小为1.7 cm（范围0.6 - 5.8）。诊断时肾计量评分的中位数为7（范围4 - 10）。总体而言，肿瘤的中位生长率为每年0.34 cm（范围 - 0.19 - 2.0）。线性回归分析显示，肿瘤年生长率与RENAL肾计量评分相关（P < 0.0001），但与诊断时的年龄、性别和初始肿瘤大小无关。此外，在26例经病理证实的肾细胞癌中，RENAL肾计量评分与年生长率之间的相关性仍然显著。
RENAL肾计量评分与肾肿块的年生长率相关。我们的研究结果进一步支持了RENAL肾计量评分与肿瘤生物学之间的关联。
