Evaluation of lung epithelial permeability.

During the last few years a number of factors affecting the measurement of the rate of absorption of 99mTc-DTPA across the alveolar-capillary membrane have been identified. These have helped to provide insights into the significance of lung epithelial permeability (LEP) measurements and their potential limitations. Pulmonary absorption of 99mTc-DTPA has been studied in a variety of clinical conditions and the results are discussed.