Coalson J J
Virchows Arch A Pathol Anat Histol. 1982;395(2):181-99. doi: 10.1007/BF00429611.
This report describes the ultrastructural findings in 37 patients who underwent open lung biopsy which yielded diagnoses of fibrosing alveolitis. A spectrum of lesions are categorized for the capillary endothelium and its basement membrane, the interstitial space and its fibrocellular components, and the alveolar epithelium and its basement membrane. The findings typify the different pulmonary cellular reactions to injury. Evidence for cellular regeneration and death in both epithelial and endothelial cell populations include atypical epithelial cell proliferation, capillary basement membrane multilamination, decrease in capillary lumen size and prominent pericytic ensheathment of pulmonary capillaries. Within the interstitium of the lung, proliferation of collagen and elastic fibers are documented, but in addition, abundant myofibroblasts and smooth muscle cells are present. No ultrastructural evidence of immune complex deposition was found in this study. The morphologic findings of fibrosing alveolitis further support the widespread concept that the lung responds to various injuries in a similar manner and undergoes a common reparative response regardless of etiology.
本报告描述了37例行开胸肺活检并确诊为纤维化肺泡炎患者的超微结构研究结果。对毛细血管内皮及其基底膜、间质间隙及其纤维细胞成分、肺泡上皮及其基底膜的一系列病变进行了分类。这些发现代表了肺细胞对损伤的不同反应。上皮细胞和内皮细胞群体中细胞再生和死亡的证据包括非典型上皮细胞增殖、毛细血管基底膜多层化、毛细血管腔大小减小以及肺毛细血管周围明显的周细胞包绕。在肺间质内，记录到胶原纤维和弹性纤维的增殖，但此外还存在大量肌成纤维细胞和平滑肌细胞。本研究未发现免疫复合物沉积的超微结构证据。纤维化肺泡炎的形态学发现进一步支持了广泛的观点，即无论病因如何，肺对各种损伤的反应相似，并经历共同的修复反应。
