• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Environment-dependent conformation and antimicrobial activity of a gramicidin S analog containing leucine and lysine residues.

作者信息

Ono S, Lee S, Kodera Y, Aoyagi H, Waki M, Kato T, Izumiya N

出版信息

FEBS Lett. 1987 Aug 17;220(2):332-6. doi: 10.1016/0014-5793(87)80841-4.

DOI:10.1016/0014-5793(87)80841-4
PMID:2440729
Abstract

An analog of gramicidin S, cyclo(-L-Leu-L-Lys-L-Leu-D-Leu-L-Leu-)2, in which four out of five amino acid components of gramicidin S were substituted, has been synthesized. This analog assumes a conformation similar to that of gramicidin S in acidic liposomes and a random conformation in neutral liposomes. The antimicrobial activity of this analog corresponded to one-fourth of that of gramicidin S. A possible mechanism for conformational changes in acidic liposomes is discussed.

摘要

相似文献

1
Environment-dependent conformation and antimicrobial activity of a gramicidin S analog containing leucine and lysine residues.
FEBS Lett. 1987 Aug 17;220(2):332-6. doi: 10.1016/0014-5793(87)80841-4.
2
[4,4'-(Z)-dehydrophenylalanine]gramicidin S with stabilized bioactive conformation and strong antimicrobial activity.
FEBS Lett. 1987 Oct 5;222(2):251-5. doi: 10.1016/0014-5793(87)80380-0.
3
Drastic reduction in antimicrobial activity by replacement of Orn residues with Lys in cyclized amphiphilic beta-structural model peptides.在环化两亲性β-结构模型肽中用赖氨酸取代鸟氨酸残基导致抗菌活性急剧降低。
Int J Pept Protein Res. 1995 Aug;46(2):97-105. doi: 10.1111/j.1399-3011.1995.tb01324.x.
4
Exploring relationships between mimic configuration, peptide conformation and biological activity in indolizidin-2-one amino acid analogs of gramicidin S.探索短杆菌肽S的中氮茚-2-酮氨基酸类似物中模拟物构型、肽构象与生物活性之间的关系。
J Pept Res. 2002 Oct;60(4):198-214. doi: 10.1034/j.1399-3011.2002.21026.x.
5
A novel, antimicrobially active analog of gramicidin S without amphiphilic conformation.一种新型的、无两亲性构象的短杆菌肽S抗菌活性类似物。
J Antibiot (Tokyo). 2006 Jun;59(6):370-2. doi: 10.1038/ja.2006.54.
6
Synthesis of low-hemolytic antimicrobial dehydropeptides based on gramicidin s.基于短杆菌肽S的低溶血抗菌脱氢肽的合成
J Med Chem. 2006 Dec 28;49(26):7592-5. doi: 10.1021/jm061051v.
7
Diastereoisomeric analogues of gramicidin S: structure, biologicalactivity and interaction with lipid bilayers.短杆菌肽S的非对映异构体类似物：结构、生物活性及与脂质双层的相互作用
Biochem J. 2000 Aug 1;349 Pt 3(Pt 3):747-55. doi: 10.1042/bj3490747.
8
Structure-activity relationships of diastereomeric lysine ring size analogs of the antimicrobial peptide gramicidin S: mechanism of action and discrimination between bacterial and animal cell membranes.短杆菌肽S抗菌肽非对映异构赖氨酸环大小类似物的构效关系：作用机制及细菌细胞膜与动物细胞膜的区分
J Biol Chem. 2005 Jan 21;280(3):2002-11. doi: 10.1074/jbc.M406509200. Epub 2004 Nov 12.
9
Synthesis and characterization of Tyr(Bzl)9,11,13,15 and Tyr9,11,13,15 gramicidin A.
Int J Pept Protein Res. 1987 Aug;30(2):163-9. doi: 10.1111/j.1399-3011.1987.tb03325.x.
10
Synthesis and characterization of (1-13C) Phe9 gramicidin A. Effects of side chain variations.（1-¹³C）苯丙氨酸⁹短杆菌肽A的合成与表征。侧链变异的影响。
Int J Pept Protein Res. 1983 Sep;22(3):341-7. doi: 10.1111/j.1399-3011.1983.tb02100.x.

引用本文的文献

1
Evolutionary conservation of human ketodeoxynonulosonic acid production is independent of sialoglycan biosynthesis.人类酮脱氧壬酮酸产生的进化保守性独立于唾液酸聚糖的生物合成。
J Clin Invest. 2021 Mar 1;131(5). doi: 10.1172/JCI137681.
2
Antimicrobial and anti-inflammatory activities of three chensinin-1 peptides containing mutation of glycine and histidine residues.含甘氨酸和组氨酸残基突变的三种陈菌素-1 肽的抗菌和抗炎活性。
Sci Rep. 2017 Jan 5;7:40228. doi: 10.1038/srep40228.
3
Effects of single D-amino acid substitutions on disruption of beta-sheet structure and hydrophobicity in cyclic 14-residue antimicrobial peptide analogs related to gramicidin S.
单个D-氨基酸取代对与短杆菌肽S相关的环状14残基抗菌肽类似物中β-折叠结构破坏和疏水性的影响。
J Pept Res. 2004 Feb;63(2):69-84. doi: 10.1046/j.1399-3011.2003.00106.x.