Heldebrant C M, Friedman A E, Fedor E J
Dev Biol Stand. 1987;67:319-22.
Alpha's Wet Heat-Treatment process is being applied to both Factor VIII (AHF) and Factor IX Complex (PTC). Twelve hemophilia A, five hemophilia B, and one von Willebrands patient have been followed for at least 6 months for evidence of non-A, non-B hepatitis. No ALT elevations were seen in the hemophilia B patients. There have been four cases of ALT elevation, three in hemophilia A patients and one in the von Willebrand's patient. A subset of these patients have been followed for over one year for anti-HTLV-III status. No patient, either hemophilia A, hemophilia B, or von Willebrand's seroconverted to anti-HTLV-III positive status. Intravenous gamma globulin was studied in 11 normal patients given a single infusion and in 23 immune deficient patients with multiple infusions and evaluations of liver enzymes over a two year period. No elevated ALT or AST values were seen in either group.
阿尔法湿热治疗法已应用于凝血因子VIII（抗血友病因子）和凝血因子IX复合物（凝血酶原复合物）。对12例甲型血友病患者、5例乙型血友病患者和1例血管性血友病患者进行了至少6个月的跟踪，以寻找非甲非乙型肝炎的证据。乙型血友病患者未出现谷丙转氨酶（ALT）升高。有4例ALT升高病例，其中3例为甲型血友病患者，1例为血管性血友病患者。对这些患者中的一部分进行了一年多的抗人类嗜T淋巴细胞病毒III型（HTLV-III）状态跟踪。无论是甲型血友病患者、乙型血友病患者还是血管性血友病患者，均未出现抗HTLV-III血清转化为阳性的情况。对11例接受单次输注的正常患者以及23例在两年期间接受多次输注并进行肝酶评估的免疫缺陷患者进行了静脉注射丙种球蛋白的研究。两组均未出现ALT或谷草转氨酶（AST）值升高的情况。
