Tanguturi Parthasaradhi Reddy, Pullareddy Bhoomireddy, Rama Krishna B S, Murthy Dwarkanath K
Department of Genetics, Osmania University, Hyderabad 500013, A.P., India.
Department of Cell and Molecular Biology, Institute of Genetics and Hospital for Genetic Diseases, Begumpet, Hyderabad 500013, A.P., India.
Indian Heart J. 2013 Dec;65(6):653-7. doi: 10.1016/j.ihj.2013.10.004. Epub 2013 Nov 13.
Studies have reported an association between lipoprotein lipase (LPL) gene and myocardial infarction in some populations. Therefore, the present study aimed to investigate the association of the HindIII polymorphism of the (LPL) gene with myocardial infarction and to explore its potential role in susceptibility in a South Indian population.
We included a total of 412 subjects (202 myocardial infarction patients and 210 age- and sex-matched controls). Demographic and clinical characteristics were collected. Lipid profiles were estimated. DNA was isolated and the LPL gene HindIII polymorphism was determined by polymerase chain reaction.
Comparison of the lipid profiles between patients and controls showed that patients had statistically high significant values (p = 0.0001). The H(+) H(+) genotype of the LPL gene is associated with myocardial infarction. H(+) H(+) vs. H(-) H(-) was χ2 = 19.4, OR 3.1, CI 95% 1.8-5.2, p < 0.0001.
Our study strongly suggests that the LPL gene HindIII Hþ Hþ genotype is an independent risk factor for first MI.
研究报告了脂蛋白脂肪酶（LPL）基因与某些人群心肌梗死之间的关联。因此，本研究旨在调查LPL基因HindIII多态性与心肌梗死的关联，并探讨其在印度南部人群易感性中的潜在作用。
我们共纳入412名受试者（202名心肌梗死患者和210名年龄及性别匹配的对照）。收集人口统计学和临床特征。评估血脂谱。分离DNA，并通过聚合酶链反应确定LPL基因HindIII多态性。
患者与对照之间血脂谱的比较显示，患者具有统计学上的高度显著值（p = 0.0001）。LPL基因的H(+) H(+)基因型与心肌梗死相关。H(+) H(+) 与H(-) H(-)比较，χ2 = 19.4，OR 3.1，95% CI 1.8 - 5.2，p < 0.0001。
我们的研究强烈表明，LPL基因HindIII Hþ Hþ基因型是首次心肌梗死的独立危险因素。
