Department of Statistics, Florida State University, Tallahassee, Florida, USA.
Theor Appl Genet. 1977 Jul;50(4):163-72. doi: 10.1007/BF00277737.
Bias in the estimation of gene number from a population of finite size will be reduced when the number of generations and the selection differential in the primary selection program are increased. A procedure to minimize bias due to dominance is proposed. Bias due to linkage disequilibrium is decreased by long generations of selection and small change of linkage disequilibrium. Bias due to inequality of gene effects was studied assuming that gene effects follow a half normal distribution. The epistatic bias arising from multiplicative gene effects disappears when the logarithms of the original measurements are considered even though the gene number estimate is unsatisfactory without transformation.
当世代数和初级选择计划中的选择差增加时，从有限大小的群体中估计基因数的偏差将会减少。提出了一种最小化由于显性引起的偏差的程序。通过选择的长世代和连锁不平衡的小变化来减少由于连锁不平衡引起的偏差。假设基因效应服从半正态分布，研究了由于基因效应不平等引起的偏差。即使在没有转换的情况下，基因数量估计不理想，当考虑原始测量的对数时，由于乘法基因效应引起的上位偏差也会消失。
