Ogawa K, Kim Y C, Nakashima Y, Yamabe H, Takeda T, Hamashima Y
Histopathology. 1987 May;11(5):511-22. doi: 10.1111/j.1365-2559.1987.tb02659.x.
Thirty-four cases of sarcomatoid carcinoma with minimal epithelial components (SC) and six cases of sarcomatous tumour without any epithelial component (ST) in various organs were studied by the immunoperoxidase technique for the expression of epithelial markers, cytokeratins and epithelial membrane antigen (EMA). Employing antibodies against both high and low molecular weight cytokeratins, sarcomatoid components in 30 examples of SC were stained positively. Epithelial membrane antigen was demonstrated in 19 out of 34 SC. The positive cells for epithelial markers within sarcomatoid components in some cases of SC, which were regarded as originating from squamous cell carcinoma, tended to be seen less frequently than in the tumours derived from adenocarcinoma or transitional cell carcinoma. In six cases of ST, stain for EMA was negative and stain for cytokeratins was positive in three examples. The immunohistochemical examination of epithelial markers in the tumours of these types may be of value in differentiating these tumours from true sarcomas.
应用免疫过氧化物酶技术检测了34例各器官中上皮成分极少的肉瘤样癌（SC）和6例无任何上皮成分的肉瘤样肿瘤（ST）中上皮标志物、细胞角蛋白和上皮膜抗原（EMA）的表达。使用抗高分子量和低分子量细胞角蛋白的抗体，30例SC中的肉瘤样成分呈阳性染色。34例SC中有19例显示上皮膜抗原阳性。在一些被认为起源于鳞状细胞癌的SC病例中，肉瘤样成分中上皮标志物的阳性细胞比起源于腺癌或移行细胞癌的肿瘤中阳性细胞出现的频率更低。在6例ST中，EMA染色阴性，3例细胞角蛋白染色阳性。对这些类型肿瘤中的上皮标志物进行免疫组化检查可能有助于将这些肿瘤与真正的肉瘤区分开来。
