Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, 27599, USA,
Curr Allergy Asthma Rep. 2014 Feb;14(2):402. doi: 10.1007/s11882-013-0402-8.
Recent investigations have expanded our knowledge of the regulatory bone marrow (BM) niche, which is critical in maintaining and directing hematopoietic stem cell (HSC) self-renewal and differentiation. Osteoblasts, mesenchymal stem cells (MSCs), and CXCL12-abundant reticular (CAR) cells are niche components in close association with HSCs and have been more clearly defined in immune cell function and homeostasis. Importantly, cellular inhabitants of the BM niche signal through G protein-coupled surface receptors (GPCRs) for various appropriate immune functions. In this article, recent literature on BM niche inhabitants (HSCs, osteoblasts, MSCs, CAR cells) and their GPCR mechanistic interactions are reviewed for better understanding of the BM cells involved in immune development, immunologic disease, and current immune reconstitution therapies.
最近的研究扩展了我们对调节性骨髓(BM)龛的认识,该龛对于维持和指导造血干细胞(HSC)自我更新和分化至关重要。成骨细胞、间充质干细胞(MSCs)和 CXCL12 丰富的网状(CAR)细胞是与 HSCs 密切相关的龛位成分,其在免疫细胞功能和稳态中的作用已得到更明确的定义。重要的是,BM 龛位的细胞居民通过各种适当的免疫功能的 G 蛋白偶联表面受体(GPCR)发出信号。本文回顾了 BM 龛位居民(HSCs、成骨细胞、MSCs、CAR 细胞)及其 GPCR 机制相互作用的最新文献,以更好地理解参与免疫发育、免疫性疾病和当前免疫重建治疗的 BM 细胞。