在突尼斯人中，银屑病与弗雷明汉十年冠心病风险评分增加有关。

Psoriasis is associated with increased Framingham ten-year risk score for coronary heart disease in Tunisians.

作者信息

Allal-El Asmi Monia, Mebazaa Amel, Zidi Wiem, Zayani Yosra, Feki Moncef, Mokni Mourad, Ben Osman Amel, Kaabachi Naziha

机构信息

Research Laboratory LR99ES11, Biochemistry Department Tunis, Tunisia.

Dermatology Department, Rabta Hospital, Tunis, Tunisia.

出版信息

Clin Lab. 2013;59(11-12):1247-52. doi: 10.7754/clin.lab.2013.121009.

DOI:10.7754/clin.lab.2013.121009

PMID:24409658

Abstract

BACKGROUND

To assess the ten-year cardiovascular risk for coronary heart disease (CHD) in psoriatic patients and to test the impact of psoriasis severity and duration on cardiovascular risk.

METHODS

A case-control study included 202 adult psoriatic patients and 202 controls.

RESULTS

Risk CHD was estimated using the Framingham risk score algorithm. Patients had a higher ten-year Framingham risk score (13.62 +/- 11.86 vs. 9.23 +/- 8.04; p = 0.002) than controls. In addition, a high risk score and a very high risk score (> 40%) were more frequent in psoriatic patients compared with controls (p = 0.043 and p < 0.001, respectively). According to the severity of psoriasis, the ten-year cardiovascular risk increases progressively and significantly (11.84 +/- 10.08; 15.59 +/- 11.79 and 16.92 +/- 14.13 for mild, moderate and severe psoriasis, respectively).

CONCLUSIONS

Psoriatic patients have significantly greater risks of developing coronary heart disease than controls in relationship with psoriasis comorbidities such as hypertension, diabetes, dyslipidemia, inflammation and probably with psoriasis itself.

摘要

背景

评估银屑病患者患冠心病（CHD）的十年心血管风险，并测试银屑病严重程度和病程对心血管风险的影响。

方法

一项病例对照研究纳入了202例成年银屑病患者和202例对照。

结果

使用弗雷明汉风险评分算法估计冠心病风险。患者的十年弗雷明汉风险评分（13.62±11.86对9.23±8.04；p = 0.002）高于对照组。此外，与对照组相比，银屑病患者中高风险评分和极高风险评分（>40%）更为常见（分别为p = 0.043和p < 0.001）。根据银屑病的严重程度，十年心血管风险逐渐且显著增加（轻度、中度和重度银屑病分别为11.84±10.08；15.59±11.79和16.92±14.13）。