Aounallah Amina, Mernissi Fatim-Zahra, Dahmani Boumediene, Bougmiza Iheb, Houria Sahel, Bouadjar Bacar, Benkaidali Ismail, Ammar-Khodja Aomar, Serradj Amina, Titi Abdelhamid, Hassam Badreddine, Benchikhi Hakima, Amal Said, Dhaoui Raouf, Turki Hamida, Doss Nejib, Denguezli Mohamed
Farhat Hached Hospital, Dermatology Department, Sousse, Tunisia.
Faculty of Medicine, Dermatology Department, Fes, Morocco.
Pan Afr Med J. 2019 Dec 19;34:205. doi: 10.11604/pamj.2019.34.205.12883. eCollection 2019.
We propose to study the epidemiological aspects of North African psoriasis and determine the cardiovascular comorbidities and addictive behaviors associated with psoriasis. This is a North African case-control study which was conducted over a five year period (October 2008 through August 2013), involving 671 psoriatic patients and 1,242 controls identified in various Algerian, Tunisian and Moroccan university hospitals. For each patient, epidemiological characteristic, addictive behaviors, and cardiovascular pathologies associated with psoriasis were noted. Six hundred and seventy one psoriasis patients and 1,242 controls were included in this study. The average age was 47.24 years and the M/F sex-ratio was 1.11 (354 men and 317 women). Statistical analysis showed that psoriasis patients were more likely to develop addictive behaviors than controls (smoking p<10-5 and alcohol consumption: p < 10-5), together with dyslipidemia (30.1% of patients p < 10-5), obesity (23.8% of patients p < 10-4), hypertension (22.3% of patients p < 10-5), diabetes (21.7% of occurrences p < 10-5) and metabolic syndrome (37.4% of patients p<10-5). The relative risk for developing psoriasis was 1.9 in hypertensive patients, 1.7 in diabetic patients, 3.9 in dyslipidemic patients, 1.8 in obese patients, 2.6 in those with metabolic syndrome, 2.1 in smokers and 2.8 in alcoholics. Our work confirms the high incidence of addictive behaviors and of cardiovascular and metabolic comorbidities during the North-African psoriasis, hence the need for a multidisciplinary comprehensive care based on a guideline suited to the characteristics of North-African psoriatic patients.
我们提议研究北非银屑病的流行病学特征，并确定与银屑病相关的心血管合并症和成瘾行为。这是一项在五年期间（2008年10月至2013年8月）开展的北非病例对照研究，涉及在阿尔及利亚、突尼斯和摩洛哥各大学医院确定的671例银屑病患者和1242例对照。对每位患者记录了与银屑病相关的流行病学特征、成瘾行为和心血管病变。本研究纳入了671例银屑病患者和1242例对照。平均年龄为47.24岁，男女比例为1.11（354名男性和317名女性）。统计分析表明，银屑病患者比对照更易出现成瘾行为（吸烟p<10-5，饮酒：p<10-5），同时伴有血脂异常（30.1%的患者p<10-5）、肥胖（23.8%的患者p<10-4）、高血压（22.3%的患者p<10-5）、糖尿病（21.7%的病例p<10-5）和代谢综合征（37.4%的患者p<10-5）。高血压患者患银屑病的相对风险为1.9，糖尿病患者为1.7，血脂异常患者为3.9，肥胖患者为1.8，代谢综合征患者为2.6，吸烟者为2.1，酗酒者为2.8。我们的研究证实了北非银屑病患者中成瘾行为以及心血管和代谢合并症的高发病率，因此需要基于适合北非银屑病患者特征的指南进行多学科综合护理。
