成年小鼠小脑颗粒细胞中一种高度丰富的转录本含有与L1同源的重复序列。

A highly abundant transcript in adult murine cerebellar granule cells contains repetitive sequences homologous to L1.

作者信息

Schaal H, Goldowitz D, Heinlein U A, Unterbeck A, Ruppert C, Papenbrock T, Müller-Hill B, Vielmetter W, Wille W

出版信息

J Neurosci. 1987 Jul;7(7):2041-8. doi: 10.1523/JNEUROSCI.07-07-02041.1987.

DOI:10.1523/JNEUROSCI.07-07-02041.1987

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6568952/

Abstract

Cloned cDNA from adult mouse cerebellum composed of subsequences homologous to the L1Md consensus sequence (long interspersed repetitive element "LINE" family of the mouse) hybridizes specifically with large nuclear poly(A)+RNAs that are highly concentrated in the murine and rat cerebellum. These homogeneous L1-related transcripts were localized in the mouse CNS by in situ hybridization with 3H- and biotin-labeled DNA probes. They were found to hybridize to cerebellar granule cells specifically.

摘要

从小鼠成年小脑克隆的cDNA，由与L1Md共有序列（小鼠的长散在重复元件“LINE”家族）同源的亚序列组成，它与大核聚腺苷酸加尾RNA特异性杂交，这些RNA在小鼠和大鼠小脑中高度富集。通过用3H和生物素标记的DNA探针进行原位杂交，这些均一的L1相关转录本在小鼠中枢神经系统中定位。发现它们特异性地与小脑颗粒细胞杂交。

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