成纤维细胞生长因子受体 4 作为结直肠癌潜在的预后和治疗标志物。
Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer.
机构信息
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong University , Jinan, Shandong Province , China .
出版信息
Biomarkers. 2014 Feb;19(1):81-5. doi: 10.3109/1354750X.2013.876555. Epub 2014 Jan 13.
The purpose of the study was to explore the significance of FGFR4 protein expression in colorectal cancer. Immunohistochemistry showed 46.8% (148/316) tumors positive for FGFR4 and 7.3% (23/316) for adjacent normal specimens. FGFR4 positivity was correlated with shortened disease free survival (DFS) and overall survival (OS). Multivariate analysis revealed that FGFR4 was an independent prognostic factor. FGFR4 silencing markedly reduced the migration and invasion capacity of colorectal cancer cell lines. These results suggest FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.
本研究旨在探讨 FGFR4 蛋白表达在结直肠癌中的意义。免疫组织化学显示，46.8%（148/316）的肿瘤 FGFR4 阳性，7.3%（23/316）的相邻正常标本 FGFR4 阳性。FGFR4 阳性与无病生存期（DFS）和总生存期（OS）缩短相关。多变量分析显示，FGFR4 是独立的预后因素。FGFR4 沉默显著降低了结直肠癌细胞系的迁移和侵袭能力。这些结果表明，FGFR4 是结直肠癌潜在的预后和治疗标志物。
Zotero 插件