成纤维细胞生长因子受体4作为三阴性乳腺癌的预后指标
Fibroblast growth factor receptor 4 as a prognostic indicator in triple-negative breast cancer.
作者信息
Wei Wei, Cao Shiyu, Liu Jing, Wang Yuhang, Song Quanfu, A Leha, Sun Shanshan, Zhang Xianyu, Liang Xiaoshuan, Jiang Yongdong
机构信息
Department of Breast Surgery, Zhujiang Hospital of Southern Medical University, Guangzhou, China.
Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
出版信息
Transl Cancer Res. 2020 Nov;9(11):6881-6888. doi: 10.21037/tcr-20-1756.
BACKGROUND
Triple-negative breast cancer (TNBC) constitutes up to 15% of all breast cancers. It is one of the most aggressive breast cancers and is more prone to metastasize compared with other subtypes. Breast cancer patients with this subtype usually have a poor prognosis. Fibroblast growth factor receptor 4 (FGFR4) belongs to the receptor tyrosine kinase (RTK) family, and early analyses identified that FGFR4 was involved in breast cancer. However, the prognostic effect of FGFR4 on TNBC is unknown. In the present study, we investigated the association between FGFR4 and TNBC prognosis.
METHODS
A total of 282 TNBC patients were enrolled. FGFR4 protein expression was detected in these 282 TNBC patients using immunohistochemistry (IHC).
RESULTS
In the present study, FGFR4 was highly expressed in TNBC patients. Lymph node metastasis (LNM) (P=0.033) and p53 status (P=0.019) were associated with high FGFR4 expression. Univariate analysis identified high FGFR4 expression (P=0.016) as a prognostic predictor, and multivariate analysis found that high FGFR4 expression (P=0.016) was an independent prognostic factor. The Kaplan-Meier survival curve showed that high FGFR4 protein expression was correlated with poorer overall survival (OS).
CONCLUSIONS
The results of our present study show that FGFR4 protein expression is correlated with a worse prognosis in TNBC.
背景
三阴性乳腺癌（TNBC）占所有乳腺癌的比例高达15%。它是最具侵袭性的乳腺癌之一，与其他亚型相比更容易发生转移。这种亚型的乳腺癌患者通常预后较差。成纤维细胞生长因子受体4（FGFR4）属于受体酪氨酸激酶（RTK）家族，早期分析发现FGFR4与乳腺癌有关。然而，FGFR4对TNBC的预后影响尚不清楚。在本研究中，我们调查了FGFR4与TNBC预后之间的关联。
方法
共纳入282例TNBC患者。使用免疫组织化学（IHC）检测这282例TNBC患者的FGFR4蛋白表达。
结果
在本研究中，FGFR4在TNBC患者中高表达。淋巴结转移（LNM）（P = 0.033）和p53状态（P = 0.019）与FGFR4高表达相关。单因素分析确定FGFR4高表达（P = 0.016）为预后预测指标，多因素分析发现FGFR4高表达（P = 0.016）是独立的预后因素。Kaplan-Meier生存曲线显示，FGFR4蛋白高表达与较差的总生存期（OS）相关。
结论
我们目前的研究结果表明，FGFR4蛋白表达与TNBC预后较差相关。
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