Priyanka Karunanidhi, Singh Sanjay
Department of Pharmaceutics, Indian Institute of Technology (Banaras Hindu University), Varanasi - 221005 (U.P), India.
Curr Drug Targets. 2014 Feb;15(2):184-98. doi: 10.2174/1389450115666140113100338.
Administration of drugs through skin via transdermal route is a non-invasive approach and applicable for systemic delivery but it is not suitable for drugs having higher molecular weight. Various approaches have been used to improve the efficacy of transdermal route such as vesicular system, iontophoresis, microneedles, use of permeation enhancers, etc. Among the several approaches, vesicular delivery is gaining importance in transdermal drug delivery. Transfersomes are one of the vesicular systems and they are best suited for the transdermal delivery of higher molecular weight compounds. Due to the deformable nature of transfersomes, they penetrate into deeper layers of skin, retain their original structure after penetration and finally enter into the systemic circulation. This review focuses mainly on the applications of transfersomes in the field of drug delivery i.e. delivery of analgesics, anti-cancers, proteins and peptides, immunomodulators, steroidal hormones and herbal drugs with increased penetration through skin. In addition, this review also deals with preparation methods available for preparing transfersomes, characterization, mechanism of penetration upon topical application and its kinetic aspects.
通过透皮途径经皮肤给药是一种非侵入性方法，适用于全身给药，但不适用于分子量较高的药物。已采用各种方法来提高透皮途径的疗效，如囊泡系统、离子导入、微针、使用渗透促进剂等。在几种方法中，囊泡递送在透皮给药中越来越重要。传递体是囊泡系统之一，它们最适合于高分子量化合物的透皮递送。由于传递体的可变形性质，它们可渗透到皮肤的更深层，渗透后保持其原始结构，最终进入体循环。本综述主要关注传递体在药物递送领域的应用，即通过增加皮肤渗透来递送镇痛药、抗癌药、蛋白质和肽、免疫调节剂、甾体激素和草药。此外，本综述还涉及制备传递体的可用制备方法、表征、局部应用时的渗透机制及其动力学方面。
