Rai Kavita, Gupta Yashwant, Jain Anekant, Jain Sanjay K
Pharmaceutics Research Laboratory, Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar-470 003, India.
PDA J Pharm Sci Technol. 2008 Sep-Oct;62(5):362-79.
The transdermal route of drug delivery has gained great interest of pharmaceutical research, as it circumvents number of problems associated with oral route of drug administration. The major barrier in transdermal delivery of drug is the skin intrinsic barrier, the stratum corneum, the outermost envelop of the skin that offers the principal hurdle for diffusion of hydrophilic ionizable bioactives. Recently, various strategies have been used to augment the transdermal delivery of bioactives. Mainly, they include iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, and vesicular system (liposomes, niosomes, elastic liposomes such as ethosomes and transfersomes). Among these strategies transferosomes appear promising. Transport of this vesicular system through skin and epithelial hurdle depends upon the flexibility of their membrane, which can be attained using appropriate ratio of surfactant. Transfersomes have shown immense potential in drug delivery across the skin. Recent success also demonstrates the potential of transfersome in vaccine, steroid, protein, and peptide delivery across the skin. It is also used for transporting genetic material and achieving transfection. This review highlights the various aspects of the transferosomes in the effective delivery of drug/bioactives across the skin.
药物经皮给药途径已引起药学研究的极大兴趣，因为它规避了与口服给药途径相关的诸多问题。药物经皮递送的主要障碍是皮肤固有的屏障——角质层，它是皮肤的最外层包膜，为亲水性可电离生物活性物质的扩散提供了主要障碍。最近，人们采用了各种策略来增强生物活性物质的经皮递送。主要包括离子导入法、电泳法、超声导入法、化学渗透促进剂、微针和囊泡系统（脂质体、非离子型脂质体、弹性脂质体如醇质体和传递体）。在这些策略中，传递体似乎很有前景。这种囊泡系统通过皮肤和上皮屏障的转运取决于其膜的柔韧性，这可以通过使用适当比例的表面活性剂来实现。传递体在药物经皮递送方面已显示出巨大潜力。最近的成功也证明了传递体在疫苗、类固醇、蛋白质和肽经皮递送方面的潜力。它还用于运输遗传物质并实现转染。本综述重点介绍了传递体在有效递送药物/生物活性物质经皮方面的各个方面。
